类目: 主页 > 天然产物 > 生物碱 > 血根碱

血根碱

中文名称:
血根碱
中文同义词:
血根碱;血根碱(标准品);血根鹼;SANGUINARINE 血根碱;SANGUINARINE 血根碱 标准品;血根碱.博落回提取物;假白屈菜季铵碱;血根碱40%
英文名称:
SANGUINARINE
英文同义词:
13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium;C06162;PSEUDOCHELERYTHRINE;SANGUINARIN;SANGUINARINE;3)-benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(;dimethylenedioxybenzphenanthridine;SANGUINARINE CHLORIDE ISOLATED FROM MACL EAY
CAS号:
2447-54-3
分子式:
C20H14NO4+
分子量:
332.33
EINECS号:
219-503-3
相关类别:
中药对照品;分析对照品;小分子抑制剂;对照品;小分子抑制剂,天然产物;植物提取物;标准品;对照品,标准品;医药原料;标准品-中药标准品;生物碱;标准品 -中药标准品;分析试剂-标准品;分析试剂;标准品,对照品;其他原料;化工原料;分析试剂标准品;Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;含量产品
Mol文件:
2447-54-3.mol
熔点 
205-215°C
沸点 
483.53°C (rough estimate)
密度 
1.3463 (rough estimate)
折射率 
1.5180 (estimate)
阳离子抗菌剂
血根碱(Sanguinarine,简称Sa),是由美洲血根草(Sanguinaria Canadensis)提取的一种阳离子抗菌剂,血根碱是属苯并菲啶类生物碱。血根碱有广泛的抗菌活性(包括嗜氧和厌氧细菌、致病和非致病口腔细菌)。血根碱对口腔组织(特别是牙菌斑)有直接性。血根碱牙膏和含血根碱的漱口液在市场上已销售多年,并进行了广泛的临床试验。牙膏研磨剂为磷酸二钙,锌盐为漱口液中的配料。 图1为血根碱化学结构式 临床研究结果表明,血根碱对口腔中大多数细菌有抑菌和杀菌作用,并有干扰细菌粘附于刚形成的牙膜上的作用。含血根碱提取物(SaE)/氯化锌的牙膏和漱口液的临床试验表明,用含质量分数为0.075%SaE、质量分数为2.0%或更多的氯化锌牙膏和含质量分数为0.03%SaE、质量分数为0.2%氯化锌漱口液进行试验,7位试验者牙菌斑全部减少,牙龈健康改善,其中3位经历6个月后见效。短期试验的效果还有待进一步证实。 血根碱作用机理还需要进一步探讨。氯化锌和血根碱各自对复配物活性的贡献还不清楚,市售含血根碱的牙膏是含有阳离子抗菌剂和阴离子表面活性剂(月桂基硫酸酯钠盐) 的配方,在该牙膏中血根碱(阳离子抗菌剂)仍然保持其抗菌活性,其原因还不清楚。 以上信息由Chemicalbook彤彤编辑整理。
生物活性
Sanguinarine (Sanguinarin) 是一种来源于 Sanguinaria Canadensis 的生物碱,可通过激活活性氧 (ROS) 的产生来刺激细胞凋亡。Sanguinarine 诱导的细胞凋亡与 JNK 和 NF-κB 的活化有关。
靶点
Apoptosis
体外研究
Sanguinarine (SANG)-induced apoptosis is associated with the activation of JNK and NF-κB signal pathways.To determine the effects of Sanguinarine on cell viability, 22B-cFluc cells are stimulated with different concentrations of Sanguinarine for 24 h, and then a CKK-8 assay is performed. The treatment with Sanguinarine decreases the proliferation of 22B cells in a dose-dependent manner. Meanwhile, the cytosolic extracts of 22B-cFluc cells treated with different dose of Sanguinarine are measured to detect cellular caspase-3 activity using Ac-DEVD-pNA, which is a validated caspase-3 substrate. The absorbance at 450 nm increases in a dose-dependent manner, indicating increased caspase-3 activity stimulated by Sanguinarine.
体内研究
To evaluate the apoptosis induced by Sanguinarine (SANG) in vivo, 22B-cFluc cells are inoculated subcutaneously into one flank of nude mice and xenograft models are allowed to establish. Mice are treated intravenously with 10 mg/kg of Sanguinarine. At 24, 48 and 72 h after treatment, bioluminescent imaging is performed after i.p. injection of mice with 150 mg/kg of D-luciferin substrate. Sanguinarine treatment induces an obvious increase of luminescent signal as early as 48 h after initial treatment. A sustained bioluminescent imaging (BLI) intensity increased is observed throughout the course of experiment. At 72 h after treatment, the tumors are collected and subjected to TUNEL staining for evaluating apoptosis. Compared with the control tumors, the group treated with Sanguinarine exhibits significantly more cell apoptosis, indicated by the increased green signals from the sporadic apoptotic cells.
化学性质 
溶于甲醇、乙醇溶液中,不溶于石油醚、氯仿。 来源于罂粟科植物博落回的带根全草。
用途 
用于含量测定/鉴定/药理实验等。 药理药效:具有抗菌、杀虫作用,改善肝功能、增强免疫力,有一定的抗肿瘤作用。
危险类别码 
25
安全说明 
13-45
危险品运输编号 
1544
毒性
LD50 oral in rat: 1660mg/kg
CAS号:2447-54-3
规   格:10g/20g/100g/1kg
价   格:请咨询卖家
数   量:
联系方式
 15623309010
正品保障
正规发票
闪电发货
满199包邮
英文名:SANGUINARINE
外观:
纯度:请咨询卖家
分子式:C20H14NO4+
分子量:332.33
最小起售量:10g/20g/100g/1kg
中文名称:
血根碱
中文同义词:
血根碱;血根碱(标准品);血根鹼;SANGUINARINE 血根碱;SANGUINARINE 血根碱 标准品;血根碱.博落回提取物;假白屈菜季铵碱;血根碱40%
英文名称:
SANGUINARINE
英文同义词:
13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium;C06162;PSEUDOCHELERYTHRINE;SANGUINARIN;SANGUINARINE;3)-benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(;dimethylenedioxybenzphenanthridine;SANGUINARINE CHLORIDE ISOLATED FROM MACL EAY
CAS号:
2447-54-3
分子式:
C20H14NO4+
分子量:
332.33
EINECS号:
219-503-3
相关类别:
中药对照品;分析对照品;小分子抑制剂;对照品;小分子抑制剂,天然产物;植物提取物;标准品;对照品,标准品;医药原料;标准品-中药标准品;生物碱;标准品 -中药标准品;分析试剂-标准品;分析试剂;标准品,对照品;其他原料;化工原料;分析试剂标准品;Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;含量产品
Mol文件:
2447-54-3.mol
熔点 
205-215°C
沸点 
483.53°C (rough estimate)
密度 
1.3463 (rough estimate)
折射率 
1.5180 (estimate)
阳离子抗菌剂
血根碱(Sanguinarine,简称Sa),是由美洲血根草(Sanguinaria Canadensis)提取的一种阳离子抗菌剂,血根碱是属苯并菲啶类生物碱。血根碱有广泛的抗菌活性(包括嗜氧和厌氧细菌、致病和非致病口腔细菌)。血根碱对口腔组织(特别是牙菌斑)有直接性。血根碱牙膏和含血根碱的漱口液在市场上已销售多年,并进行了广泛的临床试验。牙膏研磨剂为磷酸二钙,锌盐为漱口液中的配料。 图1为血根碱化学结构式 临床研究结果表明,血根碱对口腔中大多数细菌有抑菌和杀菌作用,并有干扰细菌粘附于刚形成的牙膜上的作用。含血根碱提取物(SaE)/氯化锌的牙膏和漱口液的临床试验表明,用含质量分数为0.075%SaE、质量分数为2.0%或更多的氯化锌牙膏和含质量分数为0.03%SaE、质量分数为0.2%氯化锌漱口液进行试验,7位试验者牙菌斑全部减少,牙龈健康改善,其中3位经历6个月后见效。短期试验的效果还有待进一步证实。 血根碱作用机理还需要进一步探讨。氯化锌和血根碱各自对复配物活性的贡献还不清楚,市售含血根碱的牙膏是含有阳离子抗菌剂和阴离子表面活性剂(月桂基硫酸酯钠盐) 的配方,在该牙膏中血根碱(阳离子抗菌剂)仍然保持其抗菌活性,其原因还不清楚。 以上信息由Chemicalbook彤彤编辑整理。
生物活性
Sanguinarine (Sanguinarin) 是一种来源于 Sanguinaria Canadensis 的生物碱,可通过激活活性氧 (ROS) 的产生来刺激细胞凋亡。Sanguinarine 诱导的细胞凋亡与 JNK 和 NF-κB 的活化有关。
靶点
Apoptosis
体外研究
Sanguinarine (SANG)-induced apoptosis is associated with the activation of JNK and NF-κB signal pathways.To determine the effects of Sanguinarine on cell viability, 22B-cFluc cells are stimulated with different concentrations of Sanguinarine for 24 h, and then a CKK-8 assay is performed. The treatment with Sanguinarine decreases the proliferation of 22B cells in a dose-dependent manner. Meanwhile, the cytosolic extracts of 22B-cFluc cells treated with different dose of Sanguinarine are measured to detect cellular caspase-3 activity using Ac-DEVD-pNA, which is a validated caspase-3 substrate. The absorbance at 450 nm increases in a dose-dependent manner, indicating increased caspase-3 activity stimulated by Sanguinarine.
体内研究
To evaluate the apoptosis induced by Sanguinarine (SANG) in vivo, 22B-cFluc cells are inoculated subcutaneously into one flank of nude mice and xenograft models are allowed to establish. Mice are treated intravenously with 10 mg/kg of Sanguinarine. At 24, 48 and 72 h after treatment, bioluminescent imaging is performed after i.p. injection of mice with 150 mg/kg of D-luciferin substrate. Sanguinarine treatment induces an obvious increase of luminescent signal as early as 48 h after initial treatment. A sustained bioluminescent imaging (BLI) intensity increased is observed throughout the course of experiment. At 72 h after treatment, the tumors are collected and subjected to TUNEL staining for evaluating apoptosis. Compared with the control tumors, the group treated with Sanguinarine exhibits significantly more cell apoptosis, indicated by the increased green signals from the sporadic apoptotic cells.
化学性质 
溶于甲醇、乙醇溶液中,不溶于石油醚、氯仿。 来源于罂粟科植物博落回的带根全草。
用途 
用于含量测定/鉴定/药理实验等。 药理药效:具有抗菌、杀虫作用,改善肝功能、增强免疫力,有一定的抗肿瘤作用。
危险类别码 
25
安全说明 
13-45
危险品运输编号 
1544
毒性
LD50 oral in rat: 1660mg/kg
商家信息
灵灵九 点击在线咨询 联系电话:15623309010 邮       箱:1287744812@qq.com 公司名称:武汉灵灵九生物科技有限公司
子分类
推荐商品
优质服务
客服电话 1562309010
正品保障 正品保障  提供发票
急速物流 现货闪电  当时发货
售后无忧 不满意退货