异牡荆黄素

中文名称:

异牡荆黄素

中文同义词:

异牡荆黄素, 来源于山楂树;异牡荆素(UNDER DEVELOPMENT);异黄链霉素;异牡荆黄素;4H-1-BENZOPYRAN-4-ONE,6-尾-D-GLUCOPYRANOSYL-5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-

英文名称:

ISOVITEXIN

英文同义词:

APIGENIN-6-C-GLUCOSIDE;HOMOVITEXIN;SAPOMARETOM;SAPONARETIN;Isovitexin, froM Crataegus pinnatifida;ISOVITEXIN; APIGENIN 6-C-Β-D-GLUCOSIDE;6-C-Glucosylapigenin;C01714

CAS号:

38953-85-4

分子式:

C21H20O10

分子量:

432.38

EINECS号:

相关类别:

合成;标准品;高纯试剂;植物提取物;植提标准品;对照品;标准品，对照品;对照品-中药对照品;黄酮;标准品 -中药标准品

Mol文件:

38953-85-4.mol

熔点 

257-258 °C

沸点 

807.0±65.0 °C(Predicted)

密度 

1.686±0.06 g/cm3(Predicted)

储存条件 

2-8°C

酸度系数(pKa)

5.93±0.40(Predicted)

形态

neat

BRN 

66651

简介

异牡荆黄素是从亚洲水稻种得到的黄酮类物质，具有抗氧化、抗炎的活性；Isovitexin 作用与 JNK1/2 的抑制剂类似，能够抑制 NF-κB 的活化。

生物活性

Isovitexin 是从亚洲水稻种得到的黄酮类物质，具有抗氧化、抗炎的活性；Isovitexin 作用与 JNK1/2 的抑制剂类似，能够抑制 NF-κB 的活化。

靶点

JNK1 JNK2 NF-κB

JNK1

JNK2

体外研究

Isovitexin protects against LPS-induced oxidative damage by suppressing intracellular ROS generation, and also attenuates the effect of H 2 O 2 on cell viability. Isovitexin (0-100 μg/mL) with LPS (2 μg/mL) is not cytotoxic to RAW 264.7 cells, but 200 μg/mL Isovitexin shows significant cytotoxicity. Isovitexin (25, 50 μg/mL) inhibits LPS-induced increases in TNF-α, IL-6, iNOS, and COX-2 levels. Isovitexin (25, 50 μg/mL) also suppresses the IκBα phosphorylation and degradation in RAW 264.7 cells, and such an effect is consistent with that of JNK1/2 inhibitor.

体内研究

Isovitexin (50 and 100 mg/kg, i.p.) causes less severe histopathological changes in the lung sections, and reduces inflammatory cell count in LPS-induced mice. Isovitexin (50 and 100 mg/kg, i.p.) protects against LPS-induced inflammation and oxidative stress in LPS-induced ALI mice by decreasing TNF-α and IL-6 production, ROS generation, and MPO and MDA content, increasing SOD and GSH levels and effectively inhibiting the protein expression of iNOS and COX-2. Isovitexin (25, 50, 100 mg/kg) dose-dependently reduces the survival rate of LPS/D-gal induced hepatic injury in mice. Isovitexin also inhibits NF-κB activation and up-regulates Nrf2 and HO-1 induced by LPS/D-gal in mice.

化学性质 

淡黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于山楂叶，竹叶，新西兰牡荆 Vitex lucens，滨牡荆 Virex littoralis，皂荚 Gleditsia sinensis [Syn．Gleditsia horrida]，酸角 Tamarindus indica，亚麻 Linum usitatissimum，獐牙菜 Swertia pseudochinensis．。

用途 

异牡荆素具有抗炎、抗氧化、抗肿瘤、降血压的作用。

WGK Germany 

3

海关编码 

29329990