黄花夹竹桃黄酮

中文名称:

黄花夹竹桃黄酮

中文同义词:

黄花夹竹桃黄酮

英文名称:

5-O-METHYLAPIGENIN

英文同义词:

5-O-METHYLAPIGENIN;4,7-Dihydroxy-5-methoxyflavone;Apigenin 5-methylether;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;Apigenin 5-O-monomethyl ether;Apigenin-5-methyl ether,5-0-Methylapigenin;Flavone,4,7-dihydroxy-5-methoxy- (8CI)

CAS号:

29376-68-9

分子式:

C16H12O5

分子量:

284.26

EINECS号:

相关类别:

黄酮;Miscellaneous Natural Products

Mol文件:

Mol File

熔点 

263℃

沸点 

567.9±50.0 °C(Predicted)

密度 

1.420

酸度系数(pKa)

6.67±0.40(Predicted)

应用

黄花夹竹桃黄酮抑制兔中性白细胞分泌β-葡萄糖醛酸酶，ED50为20μM；黄花夹竹桃黄酮抑制肌质网状组织Ca2+-ATPase，浓度为100μM时，抑制率69%。

制备

从刺山柑中获得精制提取物的方法，其特征在于，该方法包括以下步骤：a)使浓缩的刺山柑粗提物上大孔吸附树脂层析，依次用水和20-30％的乙醇溶液洗脱；b)再用50-100％的乙醇溶液洗脱，即得刺山柑精制提取物。所述总吲哚的主要化学成分为6-methoxybrassicanalA、6-methoxyspirobrassinin、3-醛基吲哚、3-醛基-4-羟基吲哚和Arvelexin。所述总黄酮的主要化学成分为槲皮素-3-芸香糖苷、山奈酚-3-芸香糖苷、黄花夹竹桃黄酮、金圣草素、樱花素、银杏黄素和异银杏黄素。

生物活性

Thevetiaflavone 可以上调 Bcl‑2 的表达，下调 Bax 和 caspase-3 的表达。

靶点

Bcl-2 Bax Caspase-3

Bcl-2

Bax

体外研究

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.