WARANGALONE

中文名称:

WARANGALONE

中文同义词:

攀登鱼藤异黄酮

英文名称:

warangalone

英文同义词:

warangalone;5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)-6-pyrano[3,2-g][1]benzopyranone;Warangalone (Scandenolone);2H,6H-Benzo[1,2-b:5,4-b]dipyran-6-one,5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-buten-1-yl)-;Scandenolone;5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one

CAS号:

4449-55-2

分子式:

C25H24O5

分子量:

404.46

EINECS号:

相关类别:

标准品;植物提取物;标准品 -对照药材;黄酮

Mol文件:

4449-55-2.mol

熔点 

164-165 °C

沸点 

627.0±55.0 °C(Predicted)

密度 

1.258±0.06 g/cm3(Predicted)

酸度系数(pKa)

6.39±0.40(Predicted)

生物活性

Warangalone 是抗疟疾化合物，能够抑制 3D7 (氯喹敏感) 和 K1 (氯喹耐药) 寄生虫的生长， IC50 值分别为 4.8 μg/mL 和 3.7 μg/mL。 Warangalone 还可以抑制环 AMP 依赖性蛋白激酶催化亚基 (cAK)，其 IC50 值为 3.5 μM。

靶点

IC50: 4.8 μg/mL (3D7), 3.7 μg/mL (K1) IC50: 3.5 μM (cAK)

体外研究

Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC 50 s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC 50 of 3.5 μM. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells.