条叶蓟素

中文名称:

条叶蓟素

中文同义词:

条叶蓟素;中国蓟醇

英文名称:

6,7-DIMETHOXY-3,4,5-TRIHYDROXYFLAVONE

英文同义词:

CIRSILIOL;6,7-DIMETHOXY-3,4,5-TRIHYDROXYFLAVONE 95+%;3-Hydroxy-6-methoxygenkwanin;6-Hydroxyluteolin-6,7-dimethyl ether;6-Methoxyluteolin 7-methyl ether;Crisiliol;6,7-DIMETHOXY-3,4,5-TRIHYDROXYFLAVONE;6,7-DIMETHOXY-5,3,4-TRIHYDROXYFLAVONE

CAS号:

34334-69-5

分子式:

C17H14O7

分子量:

330.29

EINECS号:

相关类别:

分析试剂标准品;黄酮;Flavones

Mol文件:

34334-69-5.mol

熔点 

280-281.5℃ (methanol )

储存条件 

2-8°C

形态

powder

颜色

white to beige

生物活性

Cirsiliol是有效和选择性的5-脂氧合酶 (5-lipoxygenase) 抑制剂，并且是竞争性低亲和力的苯二氮卓受体配体。

靶点

5-Lipoxygenase

5-Lipoxygenase

体外研究

In concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca 2+ influx but stimulates Ca 2+ release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression.

体内研究

In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone.

WGK Germany 

3

RTECS号

DJ3011100