苦参新醇 A

中文名称:

苦参新醇 A

中文同义词:

苦参醇A;苦参新醇 A;苦参新醇A标准品;苦参新醇A对照品

英文名称:

Leachianone E

英文同义词:

Kushenol A;Leachianone E;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-

CAS号:

99217-63-7

分子式:

C25H28O5

分子量:

408.49

EINECS号:

相关类别:

标准品;植物提取物;对照品;新品推荐;黄酮;标准品，对照品

Mol文件:

99217-63-7.mol

熔点 

175-178 °C

沸点 

581.7±50.0 °C(Predicted)

密度 

1.212±0.06 g/cm3(Predicted)

酸度系数(pKa)

7.66±0.40(Predicted)

生物活性

Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，可阻止 L-tyrosinase 转化为 L-DOPA，IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM; Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。

靶点

IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)

体外研究

Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM.Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells. Cell Viability Assay Cell Line: NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: Exhibited considerable cytotoxic effects against NSCLC cells.

Cell Line:

NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B

Concentration:

0-60 μg/ml

Incubation Time:

24 hours

Result:

Exhibited considerable cytotoxic effects against NSCLC cells.