异懈皮苷

中文名称:

异懈皮苷

中文同义词:

异懈皮苷;异槲皮苷,异槲皮素;异懈皮苷, 来源于草棉;3,3′,4′,5,7-五羟基黄酮 3-Β-葡萄糖甙;槲皮素 3-Β-D-葡萄糖甙;槲皮素3-葡萄糖苷;异槲皮苷(异槲皮素,异栎素,罗布麻甲素,槲皮素-3-O-葡萄糖苷,槲皮素-3-O-Β-D-吡喃葡萄糖苷);异槲皮苷(分析标准品)

英文名称:

ISOQUERCITRIN

英文同义词:

anosyloxy)-;Isoquercitrin/Isoquercetin;glucosyl3-quercetin;hirsutrin;quercetin3-beta-glucoside;quercetin3-beta-o-glucoside;quercetin3-d-glucoside;quercetin3-monoglucoside

CAS号:

482-35-9

分子式:

C21H20O12

分子量:

464.38

EINECS号:

640-533-1

相关类别:

食品和饮料标准品;植物生化提取物;植物提取;标准品;标准品-对照品;分析试剂标准品;植物提取物;Antineoplastic;标准品，对照品;黄酮;标准品 -中药标准品;其他原料;主营推荐产品

Mol文件:

482-35-9.mol

熔点 

230 °C

沸点 

872.6±65.0 °C(Predicted)

密度 

1.87±0.1 g/cm3(Predicted)

FEMA 

4225 | ISOQUERCITRIN, ENZYMATICALLY MODIFIED

储存条件 

2-8°C

形态

neat

酸度系数(pKa)

6.17±0.40(Predicted)

BRN 

100989

InChIKey

OVSQVDMCBVZWGM-QSOFNFLRSA-N

生物活性

Isoquercetin (Quercetin 3-glucoside) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。Isoquercetin 通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。Isoquercetin 通过调节核因子-κB (NF-κB) 转录调节系统调节一氧化氮合酶 2 (NO2) 的表达。Isoquercetin 具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。

靶点

Target Value Wnt/β-catenin ()

Target

Value

Wnt/β-catenin ()

体外研究

Isoquercetin (Quercetin 3-glucoside; 5-20 μM; 24 hours) substantially reduces ethanol-induced cytotoxicity , protects hepatic cells against ethanol-stimulated liver injury. Isoquercetin (10 μM; pre-treat 1 hour) dramatically downregulates the levels of ethanol-induced iNOS protein expression in HepG2 cells. Cell Viability Assay Cell Line: HepG2 cells Concentration: 5 μM, 10 μM, 20 μM Incubation Time: 24 hours Result: Caused significantly enhanced cell viability as positive controls. Western Blot Analysis Cell Line: HepG2 cells Concentration: 10 μM Incubation Time: 1 hour Result: Decreased ethanol‐ induced iNOS protein expression.

Cell Line:

HepG2 cells

Concentration:

5 μM, 10 μM, 20 μM

Incubation Time:

24 hours

Result:

Caused significantly enhanced cell viability as positive controls.

Cell Line:

HepG2 cells

Concentration:

10 μM

Incubation Time:

1 hour

Result:

Decreased ethanol‐ induced iNOS protein expression.

化学性质 

黄色粉末，易溶于甲醇，几乎不溶于水，来源于罗布麻、桑叶。

用途 

草药产品分析的标准品。

危险品标志 

Xi

安全说明 

24/25

WGK Germany 

3

RTECS号

LK8960000

F 

10-23

海关编码 

29389090

毒性

LD50 intraperitoneal in mouse: > 5gm/kg