麦冬高异黄酮A

中文名称:

麦冬高异黄酮A

中文同义词:

甲基麦冬二氢高异黄酮A;甲基麦冬黄烷酮A;麦冬高异黄酮A,甲基麦冬黄烷酮A;甲基麦冬二氢高异黄酮A,甲基麦冬黄烷酮A;麦冬甲基黄烷酮A;甲基麦冬二氢高异黄酮A(麦冬高异黄酮A,甲基麦冬黄烷酮A);甲基麦冬二氢高异黄酮A(麦冬高异黄酮A;麦冬高异黄酮A

英文名称:

Methylophiopogonanone A

英文同义词:

Methylophiopogonanone A;(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one;Methylophiopogonanone A(R-Methylophiopogonanone A);8-Methylophiopogonanone A;(3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one;R-Methylophiopogonanone A;Methylophiopogonanone A (MO-A);4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)-

CAS号:

74805-92-8

分子式:

C19H18O6

分子量:

342.34

EINECS号:

相关类别:

分析试剂标准品;植物提取物;对照品;植提标准品;中药对照品;标准品;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;黄酮;标准品 -中药标准品;标准品，对照品;标准品-对照品

Mol文件:

74805-92-8.mol

沸点 

580.1±50.0 °C(Predicted)

密度 

1.410

酸度系数(pKa)

8.24±0.40(Predicted)

生物活性

Methylophiopogonanone A 是从 Ophiopogon japonicas 提取到的黄酮类化合物，具有抗氧化和抗炎作用。

体外研究

Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L).

体内研究

Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury.

化学性质 

可溶于甲醇、乙醇、DMSO等有机溶剂，来源于麦冬须根Ophiopogon japonicus．。

用途 

甲基麦冬黄烷酮A具有提高蛋白酶活性，调节细胞骨架重建的作用。

用途 

含量测定/鉴定/药理实验等