高良姜素

中文名称:

高良姜素

中文同义词:

3,5,7-三羟基黄酮;高良姜精;高良姜素;GALANGIN 高良姜素;3,5,7-三羟基-2-苯基-4H-苯并吡喃-4-酮;高良姜素(高良姜精,高良姜黄素,3,5,7-三羟基黄酮);高良姜素, 来源于高良姜;高良姜精,高良姜黄素,3,5,7-三羟基黄酮

英文名称:

Galangin

英文同义词:

4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-phenyl;Galengin;3,5,7-Trihydroxy-2-phenyl-4h-benzopyran-4-one;Galangin Standard;Galangin, 98%, from Alpinia officinarum;3,5,7-Trihydroxy-2-phenyl-4H-chroMen-4-one;Galangin, froM Alpinia officinaruM;Galangin, >=98%

CAS号:

548-83-4

分子式:

C15H10O5

分子量:

270.24

EINECS号:

208-960-4

相关类别:

芳烃衍生物;杂环;植物提取物;中药对照品;标准品;分析标准品;标准品-中药标准品;对照品;Antineoplastic;植提标准品;植物生化提取物;中药标准品;分析对照品;分析试剂标准品;标准品-对照品;有机原料;标准品，对照品;黄酮;标准品 -中药标准品;分析试剂-对照品;医药原料;Flavanols;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

548-83-4.mol

熔点 

214-215 °C(lit.)

沸点 

333.35°C (rough estimate)

密度 

1.2319 (rough estimate)

折射率 

1.6000 (estimate)

储存条件 

room temp

酸度系数(pKa)

6.32±0.40(Predicted)

Merck 

14,4339

BRN 

272179

InChIKey

VCCRNZQBSJXYJD-UHFFFAOYSA-N

CAS 数据库

548-83-4(CAS DataBase Reference)

用途

高良姜是一种在高良姜、高良姜和蜂胶中发现的黄烷类物质。高良姜已被证明可以抑制雌激素受体阳性的MCF-7人乳腺癌细胞的增殖，并延缓乳腺肿瘤的发生。

生物活性

Galangin (Norizalpinin) 是 arylhydrocarbon 受体的调节剂，同时抑制 CYP1A1 的活性。

体外研究

Galangin (Norizalpinin) inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.

化学性质 

淡黄色结晶粉末，易溶于乙醇、乙醚，来源于姜科植物高良姜（Alpinia officinarum Hance）根。

用途 

高良姜素具有抗病毒，镇痛，止呕的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:具有抗病毒作用，能使鼠伤寒沙门氏菌TA98和TA100发生诱变。

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-37/39

WGK Germany 

3

RTECS号

LK9275500

F 

10

海关编码 

29329990