(4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮

中文名称:

(4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮

中文同义词:

(4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮

英文名称:

Hirsutene

英文同义词:

Hirsutenone;(4E)-1,7-Bis(3,4-dihydroxyphenyl)-4-hepten-3-one;4-Hepten-3-one, 1,7-bis(3,4-dihydroxyphenyl)-, (4E)-;Hirsutenone >=95% (LC/MS-ELSD)

CAS号:

41137-87-5

分子式:

C19H20O5

分子量:

328.36

EINECS号:

相关类别:

标准品;植物提取物;其它酚类

Mol文件:

41137-87-5.mol

沸点 

622.0±55.0 °C(Predicted)

密度 

1.313±0.06 g/cm3(Predicted)

储存条件 

-20°C

酸度系数(pKa)

9.76±0.10(Predicted)

生物活性

Hirsutenone 是桤木中含有的一种活性二庚酮，具有抗炎、抗肿瘤和抗特应性皮炎等多种生物活性。Hirsutenone 减弱脂肪形成，可以直接与 PI3K 和 ERK1 以非 ATP 竞争的方式结合。Hirsutenone 可用于肥胖的研究。

体外研究

Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes.Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes.Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase.

危险品标志 

N

危险类别码 

50

安全说明 

61

危险品运输编号 

UN 3077 9 / PGIII

WGK Germany 

3