曲札芪苷

中文名称:

曲札芪苷

中文同义词:

曲札芪苷;白皮杉醇-3-O-葡萄糖苷;曲札茋苷;曲札茋苷、白皮杉醇-3-O-葡萄糖苷;反式-白皮杉醇-3-O-葡萄糖苷;白皮杉醇-3-O-葡萄糖苷标准品;白皮杉醇-3-O-葡萄糖苷对照品

英文名称:

Piceatannol 3-O-glucoside

英文同义词:

Piceatannol 3;Piceatannol 3-O-glucoside;Quzhaqigan;Piceatannol 3-O-beta-D-glucopyranoside;trans-Piceatannol 3-glucoside;(E)-1-(3,5-dihydroxyphenyl)-2-(3-hydroxy-4-O-β-D-glucopyranose phenyl)ethylene;3,5,3,4-trihydroxy-stilbene -3-b-D-glucoside;Piceatannol 3-glycoside

CAS号:

94356-26-0

分子式:

C20H22O9

分子量:

406.38

EINECS号:

相关类别:

植物提取物;标准品;分析试剂标准品;对照品;标准品-对照品;其它酚类;标准品 -中药标准品;标准品，对照品

Mol文件:

94356-26-0.mol

沸点 

721.6±60.0 °C(Predicted)

密度 

1.593±0.06 g/cm3(Predicted)

酸度系数(pKa)

9.16±0.10(Predicted)

生物活性

Piceatannol 3-O-glucoside 是 Rhubarb 的一种活性成分，通过抑制精氨酸酶 (Arginase) 活性激活内皮细胞一氧化氮合酶 (NO synthase)，抑制 Arginase I 和 Arginase II，IC50 值分别为 11.22 μM 和 11.06 μM。

靶点

NO synthase IC50: 11.22 μM (Arginase I), 11.06 μM (Arginase II)

体外研究

Piceatannol 3-O-glucoside (Piceatannol-3-O-β-D-glucopyranoside; PG) is a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates, respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of Piceatannol 3-O-glucoside markedly blocks arginase activity and increases nitrite and nitrate (NOx) production, as measured by Griess assay. In liver lysates, incubation of different concentrations of Piceatannol 3-O-glucoside significantly decreases arginase I activity (75±5% at 1 µM, 72±7% at 3 µM, 62±1% at 10 µM) compared to untreated control (100±9%). In kidney lysates, the residual arginase activities after incubation of 1, 3 and 10 µM Piceatannol 3-O-glucoside are 75±6, 74±5, and 53±8%, respectively. Arginase activity is measured in the presence of different concentration of Piceatannol 3-O-glucoside (from 0 to 120 µM) using liver lysate and kidney lysate. The 50% inhibitory concentrations (IC 50 ) are 11.22 µM for the liver lysate and 11.06 µM for kidney lysate. The values are obtained using the software of Graphpad prizm 4.0. Piceatannol 3-O-glucoside inhibits arginase activity and increases NO production in HUVECs. Piceatannol 3-O-glucoside inhibits lipoxygenase activity upto 66% at the concentration of 100 µM and IC 50 value is 69 µM.

体内研究

In order to ascertain whether Piceatannol 3-O-glucoside (PG) ameliorates vascular function in wild-type (WT) and atherogenic model mice [apolipoprotein E-null mice (ApoE -/- )] and to investigate the possible underlying mechanism. Preincubation of aortic vessels from WT mice fed a normal diet (ND) with Piceatannol 3-O-glucoside attenuates vasoconstriction response to U46619 and phenylephrine (PE), while the vasorelaxant response to acetylcholine (Ach) is markedly enhanced in an endothelium-dependent manner. Piceatannol 3-O-glucoside treatment attenuates the phenylephrine (PE)-dependent contractile response, and significantly improves the acetylcholine (Ach)-dependent vasorelaxation response in aortic rings from ApoE -/- mice fed a high-cholesterol diet (HCD). Piceatannol 3-O-glucoside administration in the drinking water significantly reduces fatty streak formation in ApoE -/- mice fed an HCD.