松茋

中文名称:

松茋

中文同义词:

(E)-3-[2-(4-羟基苯基)乙烯基]-5-甲氧基苯酚;5-甲氧基-3,4-二羟基茋;松;松芪;3-[(1E)-2-(4-羟基苯基)乙烯基]-5-甲氧基苯酚;松茋;反式-松茋

英文名称:

Pinostilbene

英文同义词:

Pinostilbene;Pistilbene;3,4-Dihydroxy-5-methoxy-trans-stilbene;3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-methoxyphenol;trans-Pinostilbene;Pinostilbene hydrate;trans-Pinostilbene hydrate;3-methoxy-4,5-dihydroxy-trans-stilbene

CAS号:

42438-89-1

分子式:

C15H14O3

分子量:

242.27

EINECS号:

694-822-2

相关类别:

试剂;植物提取物;芳烃;分析试剂标准品;中药对照品;其它酚类;标准品 -中药标准品

Mol文件:

42438-89-1.mol

熔点 

117-118℃

密度 

1.252

储存条件 

Keep in dark place,Inert atmosphere,2-8°C

溶解度 

DMSO: ≥13mg/mL

形态

powder

颜色

white to tan

用途

松茋可用于含量测定，不作其他用途。

生物活性

Pinostilbene 是 Pterostilbene 的一种主要代谢物。Pinostilbene 对结肠癌细胞有抑制作用。

体外研究

Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells. Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells. Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells. Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis. Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Cell Viability Assay Cell Line: HCT116 cells, HT29 cells Concentration: 24 hours, 48 hours Incubation Time: 0-100 μM Result: Inhibited the growth of two human colon cancer cells. Apoptosis Analysis Cell Line: HCT116 cells, HT29 cells Concentration: 20 μM, 40 μM Incubation Time: 24 hours, 48 hours Result: Caused a significant and dose-dependent increase in the percentage of cells in S phase. Cell Viability Assay Cell Line: HCT116 cells Concentration: 20 μM,40 μM Incubation Time: 24 hours, 48 hours Result: Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21 Cip1/Waf1 , while decreased the expression levels of cyclin E and p-Rb.

Cell Line:

HCT116 cells, HT29 cells

Concentration:

24 hours, 48 hours

Incubation Time:

0-100 μM

Result:

Inhibited the growth of two human colon cancer cells.

Cell Line:

HCT116 cells, HT29 cells

Concentration:

20 μM, 40 μM

Incubation Time:

24 hours, 48 hours

Result:

Caused a significant and dose-dependent increase in the percentage of cells in S phase.

Cell Line:

HCT116 cells

Concentration:

20 μM,40 μM

Incubation Time:

24 hours, 48 hours

Result:

Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21 Cip1/Waf1 , while decreased the expression levels of cyclin E and p-Rb.

危险品标志 

Xi,N

危险类别码 

37/38-41-50

安全说明 

26-39-61

危险品运输编号 

UN 3077 9 / PGIII

WGK Germany 

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