2,3-二羟基-4-甲氧基苯乙酮水合物

中文名称:

2,3-二羟基-4-甲氧基苯乙酮水合物

中文同义词:

2,3-二羟基-4-甲氧基苯乙酮水合物;2,3-二羟基-4-甲氧基苯乙酮

英文名称:

2,3-DIHYDROXY-4-METHOXYACETOPHENONE

英文同义词:

1-(2,3-DIHYDROXY-4-METHOXYPHENYL)ETHANONE;Gallacetophenone 4-O-methyl ether;NSC 46636;GALLACETOPHENONE-4-METHYL ETHER;GALLACETOPHENONE-4-METHYL ETHER;4-METHOXY-2,3-DIHYDROXYACETOPHENONE;2,3-DIHYDROXY-4-METHOXYACETOHPENONE, HYDRATE;2,3-DIHYDROXY-4-METHOXYACETOPHENONE

CAS号:

708-53-2

分子式:

C9H10O4

分子量:

182.17

EINECS号:

相关类别:

苯酚;化工原料;其它酚类;其他;Aromatic Acetophenones Derivatives (substituted)

Mol文件:

708-53-2.mol

熔点 

133 °C

沸点 

359.6±42.0 °C(Predicted)

密度 

1.284±0.06 g/cm3(Predicted)

储存条件 

Inert atmosphere,Room Temperature

酸度系数(pKa)

8.98±0.15(Predicted)

生物活性

2,3-Dihydroxy-4-methoxyacetophenone 是一种来自圆锥花草的神经保护化合物。2,3-Dihydroxy-4-methoxyacetophenone 可以改善认知功能，具有用于阿尔茨海默氏病研究的潜力。

体外研究

2,3-Dihydroxy-4-methoxyacetophenone protects HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC 50 =10.94 μM). 2,3-Dihydroxy-4-methoxyacetophenone inhibits [Ca 2+ ] accumulation in HT22 cells and has antioxidantive activity.

体内研究

2,3-dihydroxy-4-methoxyacetophenone (50mg/kg; po) improves the impairment of spatial memory induced by scopolamine.