羊蹄素

中文名称:

羊蹄素

中文同义词:

羊蹄素;2-乙酰基-1,8-二羟基-3-甲基萘;2-乙酰基-1;8-二羟基-3-甲基萘;尼泊尔羊蹄素;酸模素

英文名称:

1-(1,8-dihydroxy-3-methyl-naphthalen-2-yl)ethanone

英文同义词:

2-Acetyl-3-methyl-1,8-naphthalenediol;Musizin;Nepodin;Musizine;NSC 365795;NEPODIN (MUSIZIN);Ethanone,1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-;1-(1,8-dihydroxy-3-methyl-naphthalen-2-yl)ethanone USP/EP/BP

CAS号:

3785-24-8

分子式:

C13H12O3

分子量:

216.23

EINECS号:

相关类别:

标准品;植物提取物;中药对照品;分析试剂标准品;标准品 -中药标准品;其它酚类;Miscellaneous Natural Products;对照品

Mol文件:

3785-24-8.mol

熔点 

165-166℃ (methanol )

沸点 

357.9±22.0 °C(Predicted)

密度 

1.285±0.06 g/cm3 (20 ºC 760 Torr)

酸度系数(pKa)

5.13±0.50(Predicted)

CAS 数据库

3785-24-8

生物活性

Nepodin (Musizin) 是一种醌氧化还原酶 (PfNDH2) 抑制剂，从 Rumex crispus 中分离。Nepodin (Musizin) 通过激活 AMPK 刺激 GLUT4 向质膜的转运。Nepodin (Musizin) 具有抗糖尿病和抗疟疾的作用。

体外研究

Nepodin (Musizin) exhibits significant IC 50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively.

体内研究

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner. Animal Model: C57BL/KsJ-db/db mice Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance.

Animal Model:

C57BL/KsJ-db/db mice

Dosage:

2 mg/kg; 10 mg/kg

Administration:

Orally administration; 2-10 mg/kg; 4 weeks

Result:

Had antihyperglycemic potential and improved insulin resistance.

化学性质 

淡黄色结晶，溶于甲醇，乙醇，乙酸乙酯，不溶于水，来源于蓼科植物羊蹄或尼泊尔羊蹄的根。