异甜菊醇

中文名称:

异甜菊醇

中文同义词:

异甜菊醇;异甜菊醇, 来源于甜叶菊;异甜菊醇标准品;ISOSTEVIOL 异甜菊醇 标准品;ISOSTEVIOL 异甜菊醇;异甜菊醇、异斯特维醇;异甜菊醇, BR;异甜菊醇对照品

英文名称:

ISOSTEVIOL

英文同义词:

Isosteviol (NSC 231875);(4α,8β,13β)-13--Methyl-16-oxo-17-norkauran-18-oic acid;Ccris 6121;Nsc 231875;17-NORKAURAN-18-OIC ACID, 13-METHYL-16-OXO-, (4-ALPHA,8-BETA,13-BETA)-;ISOSTEVIOL;(4-alpha,8-beta,13-beta)-13-methyl-16-oxo-17-norkauran-18-oicacid;13-beta-kauran-18-oicacid,13-methyl-16-oxo-17-nor-8-bet

CAS号:

27975-19-5

分子式:

C20H30O3

分子量:

318.45

EINECS号:

相关类别:

标准品;提取物;中药对照品;植物提取物;对照品;标准品-对照品;对照品-中药对照品;Miscellaneous Natural Products;Chiral Reagents;Intermediates Fine Chemicals;Pharmaceuticals;标准品 -中药标准品;二萜;标准品，对照品;医药、农药及染料中间体

Mol文件:

27975-19-5.mol

熔点 

228.0 to 232.0 °C

沸点 

455.6±38.0 °C(Predicted)

密度 

1.15±0.1 g/cm3(Predicted)

储存条件 

Sealed in dry,Room Temperature

形态

neat

酸度系数(pKa)

4.69±0.60(Predicted)

生物活性

Isosteviol ((-)-Isosteviol) 是一种甜菊糖苷衍生物，是甜菊糖苷通过酸催化水解产生的。Isosteviol 抑制 DNA 聚合酶和 DNA 拓扑异构酶，并具有抗菌，抗癌和抗结核作用。

体外研究

Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10 -8 M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10 -2 M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10 -8 M vasopressin. The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca 2+ ]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca 2+ ]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present. Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 27-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.

化学性质 

白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甜菊（Stevia rebaudiana Bertoni）又名甜叶菊、甜草。

用途 

异甜菊醇具有抗高血压、降低血糖、抑制癌细胞的作用。

用途 

用于含量测定/鉴定/药理实验等

WGK Germany 

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