葫芦素 E

中文名称:

葫芦素 E

中文同义词:

葫芦素 E;葫芦苦素E;葫芦素 E, >99%;葫芦素E(葫芦苦素E);葫芦素 E, 来源于甜瓜;葫芦素E(标准品);葫芦素E对照品

英文名称:

Cucurbitacin E

英文同义词:

A-ELATERIN;ALPHA-ELATERIN;CUCURBITACIN E;CUCURBITACIN E(SH);19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,2,16-alpha,20,25-t;25-acetate;alpha-elaterine;cucurbitacine-e

CAS号:

18444-66-1

分子式:

C32H44O8

分子量:

556.69

EINECS号:

242-325-2

相关类别:

中草药成分;中药对照品;标准品;植物提取物;对照品;植提标准品;分析对照品;Tri-Terpenoids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;分析试剂标准品;标准品-对照品;标准品-中药标准品;标准品 -中药标准品;三萜;标准品，对照品

Mol文件:

18444-66-1.mol

熔点 

228-234°C

比旋光度 

D -59° (c = 0.7 in chloroform)

沸点 

545.56°C (rough estimate)

密度 

1.1059 (rough estimate)

折射率 

1.4900 (estimate)

储存条件 

-20°C

溶解度 

DMSO: soluble15mg/mL, clear

形态

powder

酸度系数(pKa)

8.51±0.70(Predicted)

颜色

white to beige

旋光性 (optical activity)

[α]/D -60 to -75°, c = 0.7 (CDCl3)

InChIKey

NDYMQXYDSVBNLL-MUYMLXPFSA-N

生物活性

Cucurbitacin E 是来自 Cucumic melo L 茎的一种天然化合物。Cucurbitacin E 显著抑制 cyclin B1/CDC2 复合物的活性。

靶点

cyclin B1/CDC2 Autophagy

cyclin B1/CDC2

Autophagy

体外研究

To explore the antitumor activity of Cucurbitacin E (CuE) against colorectal cancer (CRC) cells, an in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5 μM) over a period of 24 h. The proliferation of the Cucurbitacin E-treated cancer cells is then measured using the MTT method. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. Microscopic observation showed that following exposure to Cucurbitacin E (5 μM) between 6 and 24 h, the primary colon cancer cells underwent a remarkable change in morphology. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G 2 /M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells.

体内研究

A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Significant decrease in body weights of HFD-MetS mice treated with Cucurbitacin E (0.5mg/kg) are found as compared to HFD-MetS mice treated with vehicle alone. Cucurbitacin E treatment reduces all fat pads weights in HFD-MetS mice. 55% reduction is observed in total fat in mice, after treatment with Cucurbitacin E in comparison to HFD-MetS mice. Abdominal obesity is strongly associated with metabolic syndrome. Central obesity is reduced to 50% after Cucurbitacin E treatment as compared to HFD MetS mice, elucidating the effectiveness of Cucurbitacin E in targeting MetS.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甜瓜蒂。

用途 

葫芦素 E具有保肝,抗肿瘤(人体鼻咽癌),催吐,增强免疫的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:用于治疗慢性肝炎。1细胞毒与抗癌作用，2抗肝损害，3提高机体免疫功能。

类别

有毒物质

毒性分级

剧毒

急性毒性

口服-小鼠 LD50: 340 毫克/公斤; 腹腔-小鼠 LD50: 2 毫克/公斤

可燃性危险特性

可燃, 火场排出辛辣刺激烟雾

储运特性

库房低温, 通风, 干燥; 与食品原料分开存放

灭火剂

水, 二氧化碳, 干粉, 砂土

危险品标志 

Xn

危险类别码 

25-22

安全说明 

1-22-45-24/25

危险品运输编号 

3172

WGK Germany 

3

RTECS号

RC6305500

海关编码 

29153900

毒性

LD50 orally in mice: 340 mg/kg (Albert)