戊曲酯

中文名称:

戊曲酯

中文同义词:

缬草三酯;[(1S,6S,7aS)-4-(乙酰氧甲基)-1-(3-甲基丁酰氧基)螺[6,7a-二氢-1H-环戊并[c]吡喃-7,2-环氧乙烷]-6-基] 3-甲基丁酸酯;戊曲酯;环氧戊喃;缬草三酯(缬草素、环氧戊喃);戊曲酯,缬草三酯;缬草三酯(缬草素;VALEPOTRIATE 缬草三酯

英文名称:

Valtrate

英文同义词:

HalazuchroMe B;ValepotriatuM;ValtratuM;VALTRATE(P);[(1S,6S,7aS)-4-(Acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2-oxirane]-6-yl] 3-methylbutanoate;Valtrate;(1S,7R)-4-Acetoxymethyl-6,7aα-dihydrospiro[cyclopenta[c]pyran-7(1H),2-oxirane]-1α,6α-diol 1,6-bis(3-methylbutanoate);VALTRATE(P)(PLEASE CALL)

CAS号:

18296-44-1

分子式:

C22H30O8

分子量:

422.47

EINECS号:

242-174-2

相关类别:

中药对照品;标准品;植物提取物;对照品;分析试剂标准品;对照品-中药对照品;标准品 -中药标准品;Miscellaneous Natural Products;环烯醚萜;标准品，对照品

Mol文件:

18296-44-1.mol

沸点 

525.9±50.0 °C(Predicted)

密度 

1.22±0.1 g/cm3(Predicted)

生物活性

Valepotriate, 从 Valeriana jatamansi 分离而来，具有抗癫痫和抗癌活性。

体内研究

Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

化学性质 

黄色液体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于蛛蛛香，缬草。

用途 

缬草三酯具有抗肿瘤，抗老年痴呆的作用。

用途 

用于含量测定/鉴定/药理实验等。

海关编码 

29329990