知母皂苷BII

中文名称:

知母皂苷BII

中文同义词:

知母皂苷B2;知母皂苷BII(标准品);知母皂苷BII;知母皂苷 BII, 来源于知母;TIMOSAPONIN BII 知母皂苷BII 标准品;TIMOSAPONIN BII 知母皂苷BII;知母皂苷BⅡ(分析标准品);知母皂苷BII、原知母皂苷A3

英文名称:

Timosaponin BII

英文同义词:

Timosaponin B2;Timsaponin B-Ⅱ;Timosaponin BII;(25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol;(25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol;Anemarsaponin BII, 98%, from Anemarrhena asphodeloides Bunge;Prototimosaponin A III;β-D-Galactopyranoside, (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-

CAS号:

136656-07-0

分子式:

C45H76O19

分子量:

921.08

EINECS号:

相关类别:

中药对照品;标准品;对照品;植提标准品;对照品,标准品;植物提取物;分析试剂标准品;Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-对照品;标准品-中药标准品;对照品-中药对照品;标准品 -中药标准品;其它萜类;标准品，对照品

Mol文件:

136656-07-0.mol

沸点 

1033.6±65.0 °C(Predicted)

密度 

1.43

闪点 

573℃

酸度系数(pKa)

12.85±0.70(Predicted)

生物活性

Timosaponin BII (Prototimosaponin A III) 是在知母根茎中发现的一种甾体皂苷。Timosaponin BII 具有神经保护、抗炎和抗氧化活性。

体外研究

Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC 50 value of 15.5 μg/mL in the HL-60 cells.

体内研究

Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time.

化学性质 

可溶于甲醇、乙醇、DMSO等有机溶剂，来源于知母Anemarrhena asphodeloides。

用途 

知母皂苷BⅡ具有抑制血小板聚集的作用。

海关编码 

29389090