盐酸益母草碱

中文名称:

盐酸益母草碱

中文同义词:

益母草碱盐酸盐,益母草碱;盐酸益母草碱(益母草碱盐酸盐,益母草碱);LEONURINE HYDROCHLORIDE 盐酸益母草碱;盐酸益母草碱(3,5-二甲氧基-4-羟基-苯甲酸 (4-胍基)-1-丁酯一水合物盐酸盐);盐酸益母草碱;3,5-二甲氧基-4-羟基-苯甲酸 (4-胍基)-1-丁酯一水合物盐酸盐;益母草碱盐酸盐;盐酸益母草碱(标准品)

英文名称:

Leonurine hydrochloride

英文同义词:

Leonurine 4-Guanidino-1-butanol syringate;SCM-198;leonurine hydrochloride;4-Guanidino-1-butanol syringate;4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxy-benzoate hydrochloride;Leonurine;LEONURINE HCL;4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester

CAS号:

24697-74-3

分子式:

C14H21N3O5

分子量:

311.33

EINECS号:

683-174-6

相关类别:

中草药成分;中药对照品;标准品;对照品,标准品;植物提取物;合成;对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;植提标准品;医药原料药;标准品-对照品;标准品-中药标准品;对照品-中药对照品;生物碱;标准品 -中药标准品;标准品，对照品;原料

Mol文件:

24697-74-3.mol

熔点 

238 °C

沸点 

496.7±55.0 °C(Predicted)

密度 

1.29±0.1 g/cm3(Predicted)

储存条件 

Keep in dark place,Inert atmosphere,2-8°C

溶解度 

DMSO: soluble2mg/mL, clear (warmed)

酸度系数(pKa)

8.26±0.25(Predicted)

形态

powder

颜色

white to beige

InChIKey

WNGSUWLDMZFYNZ-UHFFFAOYSA-N

生物活性

Leonurine 是从 Herba leonuri 中分离到的生物碱，具有抗氧化、抗炎活性。

体外研究

Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.

体内研究

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于益母草。

用途 

益母草碱具有活血、祛淤、调经、消水的作用。

用途 

用于含量测定/鉴定/药理实验等 药理药效:1．对子宫的作用益母草碱对兔、猫、犬、豚鼠等多种动物的子宫均呈兴奋作用2．对循环系统的作用小剂量益母草碱对离体蛙心有增强收缩作用，使用大量时反呈抑制现象。这种抑制现象可能由于迷走神经末梢兴奋所致。

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-24/25

WGK Germany 

3

海关编码 

29399990