黄芪皂苷 I

中文名称:

黄芪皂苷 I

中文同义词:

黄芪皂苷I(标准品);黄芪皂苷 I;黄芪皂苷I, 来源于黄芪;ASTRAGALOSIDE I 黄芪皂苷I;黄芪皂苷I对照品,

英文名称:

ASTRAGALOSIDE I

英文同义词:

20,24-EPOXYCYCLOARTANE-3,16,25-TRIOL-6-O-BETA-D-GLUCOPYRANOSIDE;ASTRAGALOSIDE I;Astrasieversianin IV;Cyclosieversioside B;Cyclosiversioside B;ASTRAGALOSIDE I(SH);Astragaloside I (Astrasieversianin IV;Astragaloside l, 98%, from Astragalus membranaceus Bunge

CAS号:

84680-75-1

分子式:

C45H72O16

分子量:

869.04

EINECS号:

相关类别:

中药对照品;标准品;对照品,标准品;植物提取物;对照品;植提标准品;分析试剂标准品;Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;中药对照品-黄芪;标准品 -中药标准品;分析试剂-标准品;标准品-对照品;化工原料

Mol文件:

84680-75-1.mol

沸点 

911.8±65.0 °C(Predicted)

密度 

1.36±0.1 g/cm3(Predicted)

储存条件 

Keep in dark place,Sealed in dry,2-8°C

酸度系数(pKa)

12.87±0.70(Predicted)

概述

黄芪皂苷I从豆科植物蒙古黄芪中提取炼制，为白色结晶粉末状。目前黄芪多以药物组方的形式应用于治疗老年性痴呆，也有研究发现黄芪多糖可以改善大鼠学习记忆的作用。

生物活性

Astragaloside I 是从黄芪中分离出来的一种天然化合物。Astragaloside I 可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化，具有成骨的活性。

体外研究

Astragaloside I (10-40 μM) upregulates the express of β-catenin, Runx2, BGP and OPG, RANKL (osteogenesis marker genes) in MC3T3-E1 cells. Western Blot Analysis. Cell Line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μM. Incubation Time: 5 days. Result: Stimulated the expression of β-catenin and Runx2. Cell Cytotoxicity Assay. Cell Line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μM. Incubation Time: 1, 3 or 6 days (The media was changed every 2 days). Result: No obvious cytotoxic effect was observed in the MC3T3-E1 cells.

Cell Line:

MC3T3-E1 cells.

Concentration:

0, 10, 20, 40 μM.

Incubation Time:

5 days.

Result:

Stimulated the expression of β-catenin and Runx2.

Cell Line:

MC3T3-E1 cells.

Concentration:

0, 10, 20, 40 μM.

Incubation Time:

1, 3 or 6 days (The media was changed every 2 days).

Result:

No obvious cytotoxic effect was observed in the MC3T3-E1 cells.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于黄芪。

用途 

黄芪皂苷I具有改善心肺，扩张血管，降低血压的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:具有护心、强心，抗胃溃疡，抑制胶原增生，改善血液流变学，抗衰老，对机体免疫调节作用，保肝护肝、抗菌抗炎、降压、镇痛镇静、利尿、促进胰岛素的分泌等作用。