延胡索碱甲

中文名称:

延胡索碱甲

中文同义词:

元胡提取物 (延胡索 延胡索碱);延胡索甲素(紫堇碱,延胡索碱,(+)-紫堇碱,D-紫堇碱,紫堇块茎碱);紫堇碱, 延胡索碱, 延胡索碱甲;(+)-CORYDALINE 延胡索甲素;(十)一CORYDALINE;元胡提取物;延胡索甲素(紫堇碱,延胡索碱,(+)-紫堇碱,D-紫堇碱);(+)-紫堇碱

英文名称:

Corydaline

英文同义词:

[7S,13S,13aR,(+)]-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine;d-Corydaline;2,3,9,10-TetraMethoxy-13-Methylberbine, 8CI;Corydalis A;(13s-e)-thyl;2,3,9,10-tetramethoxy-13-alpha-methyl-13a-beta-berbin;2,3,9,10-tetramethoxy-13-methyl-berbin;6h-dibenzo(a,g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-me

CAS号:

518-69-4

分子式:

C22H27NO4

分子量:

369.45

EINECS号:

相关类别:

中草药成分;标准品-中药标准品;分析试剂标准品;标准品-对照品;对照品;中药对照品;标准品;Alkaloids;对照品,标准品;植物提取物;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;植提标准品;标准品 -中药标准品;标准品，对照品

Mol文件:

518-69-4.mol

熔点 

135°

比旋光度 

D20 +311° (c = 0.8 in alc)

沸点 

499.57°C (rough estimate)

密度 

1.1771 (rough estimate)

折射率 

1.5614 (estimate)

储存条件 

Keep in dark place,Sealed in dry,2-8°C

酸度系数(pKa)

6.57±0.40(Predicted)

InChIKey

VRSRXLJTYQVOHC-YEJXKQKISA-N

概述

延胡索甲素为季胺类生物碱，是罂粟科紫堇属植物延胡索(Corydalis yanhusuo W.T.Wang)块茎中的主要有效成分之一。现代药理学表明延胡索甲素不仅有镇痛、兴奋子 宫、抗心律失常等作用，延胡索甲素具有抗吗啡样作用，还可用于制备为戒毒药物。

应用

延胡索甲素在无毒性范围内能够有效地抑制呼吸道病毒的复制，可进一步开发为治疗或预防病毒性呼吸道疾病的药物，具有广泛的应用前景。

生物活性

Corydaline ((+)-Corydaline) 是一种从 Corydalis yanhusuo 提取的异喹啉生物碱，是一种 AChE 抑制剂，IC50 为 226 µM。Corydaline 是一种 μ 阿片受体 (μ-opioid receptor, Ki 为 1.23 µM) 激动剂，可抑制肠道病毒 71 (EV71) 复制 (IC50 为 25.23 µM)。Corydaline 具有抗血管生成，抗过敏，胃排空和抗伤害感受的作用。

靶点

IC50: 226 µM (AChE); 25.23 µM (Enterovirus 71) Ki: 1.23 µM (μ-opioid receptor)

体外研究

Corydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Corydaline could inhibit the viral RNA synthesis in a dose dependent manner. Western Blot Analysis Cell Line: Vero cells infected with EV71 Concentration: 12.5 µM, 25 µM, 50 µM Incubation Time: 24 hours Result: Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2.

Cell Line:

Vero cells infected with EV71

Concentration:

12.5 µM, 25 µM, 50 µM

Incubation Time:

24 hours

Result:

Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2.

体内研究

Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior. Animal Model: Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid Dosage: 10 mg/kg Administration: Subcutaneous administration; once Result: Showed antinociceptive effects in mice.

Animal Model:

Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid

Dosage:

10 mg/kg

Administration:

Subcutaneous administration; once

Result:

Showed antinociceptive effects in mice.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于延胡索块茎，小泉紫堇全草，深山紫堇根，马尔查紫堇块茎和地上部分。

用途 

延胡索甲素具有镇痛，镇静，催眠的作用。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:镇痛作用。

毒性

LD50 in mice (mg/kg): 135.5 ± 12.8 i.v. (Anderson, Chen)