1-脱氧野尻霉素盐酸盐

中文名称:

去氧野艽霉素盐酸盐

中文同义词:

去氧野艽霉素盐酸盐;脱氧野尻霉素盐酸盐;脱氧野尻霉素;盐酸脱氧野尻霉素;野尻霉素;化合物DUVOGLUSTAT HYDROCHLORIDE

英文名称:

Deoxynojirimycin hydrochloride

英文同义词:

DEOXYNOJIRIMICIN;DEOXYNOJIRIMYCIN;DEOXYNOJIRIMYCIN HYDROCHLORIDE;DNJ;DNJ, HCL;DNM;(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL;(+)-1-DEOXYNOJIRIMYCIN HYDROCHLORIDE

CAS号:

73285-50-4

分子式:

C6H13NO4

分子量:

163.17

EINECS号:

相关类别:

标准品;化学试剂;抗生素类;All Inhibitors;Inhibitors

Mol文件:

73285-50-4.mol

熔点 

195-196°C

储存条件 

2-8°C

形态

Powder

颜色

White

水溶解性 

Soluble in water at 20mg/ml

BRN 

3563225

CAS 数据库

73285-50-4

生物活性

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) 是一种口服有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。1-Deoxynojirimycin hydrochloride 抑制餐后血糖，预防糖尿病。1-Deoxynojirimycin hydrochloride 具有降血糖、减肥和抗病毒的作用。

体内研究

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect . 1-Deoxynojirimycin hydrochloride significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice. Animal Model: db/db mice Dosage: 20, 40, 80 mg/kg Administration: Intravenously; daily for four weeks Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.

Animal Model:

db/db mice

Dosage:

20, 40, 80 mg/kg

Administration:

Intravenously; daily for four weeks

Result:

Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.

危险品标志 

Xi

危险类别码 

36/38

安全说明 

26-36-24/25-22

WGK Germany 

3

F 

10