罗汉果提取物

中文名称:

α-倒捻子素

中文同义词:

山竺提取物;曼果斯廷;1,3,6-三羟基-7-甲氧基-2,8-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮;Α-倒捻子素(标准品);Α-倒捻子素;ALPHA-倒捻子素;楝子素;曼果斯廷对照品,

英文名称:

Mangostin

英文同义词:

α-Mangostin, 98%, from Garcinia mangostana;α-Mangostin (a-Mangostin、ALPHA-Mangostin);α-Mangostin, froM Garcinia Mangostana;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-on;Alpha-Mangostin α-Mangostin;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one;1,3,6-TRIHYDROXY-7-METHOXY-2,8-DI(3-METHYL-2-BUTENYL)XANTHONE;Mangosteen

CAS号:

6147-11-1

分子式:

C24H26O6

分子量:

410.46

EINECS号:

683-120-1

相关类别:

分析标准品;中药对照品;标准品;植物提取物;中草药成分;标准植物提取物;植提标准品;对照品;植物生化提取物;提取物;医药原料;Xanthones;Intermediates Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;standard substance;标准产品;氧杂蒽酮;标准品 -中药标准品;分析试剂-化学分析;标准品，对照品;标准提取物;标准品-对照品;主营推荐产品;植物单体;比例提取物

Mol文件:

6147-11-1.mol

熔点 

180-182°C

沸点 

640.1±55.0 °C(Predicted)

密度 

1.265±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

methanol: soluble1mg/mL, clear, very light yellow

酸度系数(pKa)

7.22±0.20(Predicted)

形态

powder

颜色

faint yellow to yellow

最大波长(λmax)

346nm(MeOH)(lit.)

InChIKey

GNRIZKKCNOBBMO-UHFFFAOYSA-N

CAS 数据库

6147-11-1(CAS DataBase Reference)

概述

α-倒捻子素是从植物山竹子中提取的一种氧杂蒽酮类化合物。此外，α-倒捻子素来源于天然山竹子的有效成分，具有安全无毒及悠久食用历史等特点，对α-倒捻子素作为药物的深入研究提供了理论和应用基础。

生物活性

alpha-Mangostin (α-Mangostin) 是具有广泛生物活性的膳食呫吨酮，如抗氧化剂，抗过敏，抗病毒，抗菌，抗炎和抗癌作用。它是IDH1突变体 (IDH1-R132H) 的抑制剂，Ki值为 2.85 μM。

靶点

IC50: 2.85 μM (IDH1-R132H)

体外研究

alpha-Mangostin (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H 2 O 2 -induced apoptosis of RPE cells. 200 μM H 2 O 2 -induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin).

体内研究

alpha-Mangostin (α-Mangostin) reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于藤黄科(Guttiferae)山竹壳、罗汉果、山竺。

用途 

α-倒捻子素具有治疗腹泻、疟疾、抗炎、抗溃疡以及抗白血病和败血病的作用。

用途 

用于含量测定/鉴定/药理实验等 药理药效:具有抗氧化、抗炎、抗菌、抗癌等药理活性

危险品标志 

T

危险类别码 

25

安全说明 

45

危险品运输编号 

UN 2811 6.1 / PGIII

WGK Germany 

1

RTECS号

ZD6122420

海关编码 

29329990