C-GPAP

中文名称:

C-GPAP

中文同义词:

CGAMP铵盐;CGAMP 钠盐

英文名称:

c-GpAp

英文同义词:

c-GpAp;di-GAMP;di-cGAMP;cGAMP (Cyclic GMP-AMP;3-Guanylic acid, adenylyl-(3?5)-, cyclic nucleotide;3,3-Cyclic guanosine monophosphate-adenosine monophosphate;cGAMP;33-cGAMP

CAS号:

849214-04-6

分子式:

C20H24N10O13P2

分子量:

674.41

EINECS号:

相关类别:

生物活性分子-API;活性分子;Nucleotides, Bases Related Reagents, Derivatives

Mol文件:

849214-04-6.mol

沸点 

1159.9±75.0 °C(Predicted)

密度 

2.61±0.1 g/cm3(Predicted)

储存条件 

-20°C

形态

powder

酸度系数(pKa)

0.96±0.70(Predicted)

颜色

white to beige

生物活性

3,3-cGAMP (3,3-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP)可激活内质网(ER)内源性受体 stimulator of interferon genes (STING) ，从而诱导抗病毒状态和I型IFN的分泌。

靶点

Target Value STING ()

Target

Value

STING ()

体外研究

cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice. cGAMP directly activates murine and human dendritic cells in vitro. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF). cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.

体内研究

cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice. Animal Model: Female C57BL/6 (H-2b) mice 6–8 weeks old Dosage: 5 µg Administration: Nostril mucosal adjuvant Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.

Animal Model:

Female C57BL/6 (H-2b) mice 6–8 weeks old

Dosage:

5 µg

Administration:

Nostril mucosal adjuvant

Result:

Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.