钒酸钠

中文名称:

钒酸钠

中文同义词:

原钒酸钠 十二水;正钒酸钠 十二水;十二水合原钒酸钠;十二水原钒酸钠;钒酸钠;正釩酸鈉;原钒酸钠, 99.9% (METALS BASIS);草酸钠 SODIUM OXALATE

英文名称:

Sodium orthovanadate

英文同义词:

(beta-4)-vanadate(vo43-trisodium;trisodiumorthovanadate;trisodiumvanadate;vanadic(ii)acid,trisodiumsalt;Vanadicacidtrisodiumsalt;SODIUM VANADATE;SODIUM VANADATE, ORTHO;Sodium orthovanadate,99%

CAS号:

13721-39-6

分子式:

H3NaOV

分子量:

92.95

EINECS号:

237-287-9

相关类别:

化学试剂;其他生化试剂;生化试剂-其他化学试剂;无机化工原料;稀有金属;催化和无机化学;小分子抑制剂，天然产物;Inorganics;Peroxidase InhibitorsCell Signaling and Neuroscience;Phosphatase InhibitorsTyrosine Phosphatase Biology;Tyrosine Phosphatase (TP)Chemical Synthesis;Enzyme Inhibitors by Enzyme;Kinase/Phosphatase Biology;P to;通用试剂;钒;小分子抑制剂;Inhibitors;生化试剂;正钒酸钠;化工材料;Catalysis and Inorganic Chemistry;Chemical Synthesis;Vanadium;Tyrosine Phosphatase Inhibitors

Mol文件:

13721-39-6.mol

熔点 

850-866 °C(lit.)

储存条件 

Sealed in dry,Room Temperature

溶解度 

H2O: soluble

形态

Solid

颜色

off-white

水溶解性 

soluble

稳定性

Stable. Incompatible with strong oxidizing agents.

CAS 数据库

13721-39-6(CAS DataBase Reference)

EPA化学物质信息

Sodium vanadium oxide (Na3VO4) (13721-39-6)

应用

钒酸钠属于无机盐化合物，主要用作催化剂、油漆催干剂、媒染剂、缓蚀剂等，也用于制备其他钒盐。

生物活性

Sodium orthovanadate是蛋白酪氨酸磷酸酶，碱性磷酸酶和一些ATP酶的抑制剂，最有可能充当磷酸盐类似物。

靶点

PPTPase.

体外研究

In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO4 2- or H2VO 4- ) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process. Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia.

用途 

几种磷酸酶和磷酸激酶的抑制剂

危险品标志 

Xn

危险类别码 

20/21/22

安全说明 

22-36

危险品运输编号 

UN3285

WGK Germany 

3

RTECS号

YW1120000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

海关编码 

28419030