NULL

中文名称:

NULL

中文同义词:

PRMT5抑制剂(HLCL-61 HYDROCHLORIDE);HLCL-61 盐酸盐

英文名称:

HLCL-61 (hydrochloride)

英文同义词:

HLCL-61 (hydrochloride);HLCL-61.HCl;HLCL61;HLCL 61;CS-2798;HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE

CAS号:

1158279-20-9

分子式:

C23H25ClN2O

分子量:

0

EINECS号:

相关类别:

细胞生物学试剂;API

Mol文件:

Mol File

储存条件 

Inert atmosphere,Store in freezer, under -20°C

生物活性

HLCL-61 hydrochloride 是首创的小分子蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂。

靶点

Protein arginine methyltransferase 5

体外研究

HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC 50 s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively. HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Cell Viability Assay Cell Line: MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients) Concentration: 1, 5, 10, 25, 50, 100 μM Incubation Time: 24, 48, 72 hours Result: Dose-dependent reduction in cell viability with IC 50 s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.

Cell Line:

MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients)

Concentration:

1, 5, 10, 25, 50, 100 μM

Incubation Time:

24, 48, 72 hours

Result:

Dose-dependent reduction in cell viability with IC 50 s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.