硫黄素 T

中文名称:

硫黄素 T

中文同义词:

2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物;碱性黄1;硫代磺素T;硫代黄色素 T;硫黄素 T;盐基嫩黄;硫磺素T;硫代黄素T

英文名称:

Thioflavine T

英文同义词:

2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride;Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride;Thioflavine T (C.I.No.49005) for synthesis;Thioflavin T (Absorbance(E1%1cm) >=750 (410 nm to 414 nm, H2O);Thioflavin T *CAS 2390-54-7*;avin T;ThiofL;LABOTEST-BB LT00451909

CAS号:

2390-54-7

分子式:

C17H19ClN2S

分子量:

318.86

EINECS号:

219-228-9

相关类别:

色素类;有机硼化合物;生化试剂;化工原料;其他生化试剂;生化试剂-色素类;化学试剂;Biochemistry;Vitamin Derivatives;Vitamins;电镀原材料;功能性添加剂化工原料;电镀添加剂;有机化工原料

Mol文件:

2390-54-7.mol

熔点 

211-212 °C (decomp)

储存条件 

Store below +30°C.

溶解度 

methanol: soluble1mg/mL

形态

Powder

色指数 

49005

颜色

Yellow to ochre-yellow

BRN 

3922452

CAS 数据库

2390-54-7(CAS DataBase Reference)

EPA化学物质信息

Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (2390-54-7)

生物活性

Thioflavin T (ThT, Basic Yellow 1) 是一种苯并噻唑染料，与淀粉样蛋白原纤维结合后显示增强的荧光，通常用于诊断淀粉样蛋白原纤维。

体外研究

Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission.

用途 

一种苯并噻唑染料，在与淀粉体连接时可提高荧光效率；用于组织学以及蛋白质表征中

安全说明 

24/25

危险品运输编号 

2811

WGK Germany 

3

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

海关编码 

32041300