血管紧张素II

中文名称:

血管紧张素II

中文同义词:

血管緊縮素 II;血管紧缩素II;ANGIOTENSIN II HUMAN 乙酸盐;人血管紧缩素II;血管紧张素 II 醋酸盐;人血管紧缩素II(-20℃)

英文名称:

ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT

英文同义词:

ANGIOTENSIN II ACETATE SALT;ANGIOTENSIN II HUMAN ACETATE SALT;ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT;HYPERTENSIN II;ANGIOTENSIN II ACETATE HUMAN;ANGIOTENSIN II-FLUORESCEIN SYNTHETIC >81 %;ANGIOTENSIN II, MASS SPEC STANDARD;ANGIOTENSIN II, HUMAN, SYNTHETIC

CAS号:

68521-88-0

分子式:

C52H75N13O14

分子量:

1106.25

EINECS号:

206-182-3

相关类别:

生物试剂;SignalTransduction;Peptide Receptors;Peptide

Mol文件:

68521-88-0.mol

储存条件 

−20°C

溶解度 

H2O: 25 mg/mL, clear, colorless

形态

powder

颜色

orange

生物活性

Angiotensin II (Ang II, DRVYIHPF)是一种八肽激素，能够影响心血管、肾脏和脑活性。它通过结合细胞膜上特定受体发挥作用。

体外研究

Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors.

体内研究

To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption.

WGK Germany 

3

F 

3-10