钙抑肽

中文名称:

钙抑肽

中文同义词:

KATACALCIN肽;钙抑肽

英文名称:

KATACALCIN

英文同义词:

KATACALCIN;KATACALCIN (HUMAN);C-PROCALCITONIN;C-PROCALCITONIN (HUMAN);CALCITONIN C-TERMINAL FLANKING PEPTIDE (HUMAN);DMSSDLERDHRPHVSMPQNAN;H-ASP-MET-SER-SER-ASP-LEU-GLU-ARG-ASP-HIS-ARG-PRO-HIS-VAL-SER-MET-PRO-GLN-ASN-ALA-ASN-OH;ASP-MET-SER-SER-ASP-LEU-GLU-ARG-ASP-HIS-ARG-PRO-HIS-VAL-SER-MET-PRO-GLN-ASN-ALA-ASN

CAS号:

85916-47-8

分子式:

C97H154N34O36S2

分子量:

2436.62

EINECS号:

相关类别:

多肽;Peptide

Mol文件:

85916-47-8.mol

密度 

1.62±0.1 g/cm3(Predicted)

储存条件 

-15°C

生物活性

Katacalcin (PDN 21) 是一种有效的具有降低血钙效应的多肽激素。

体外研究

Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14 + peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14 + PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14 + PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14 + PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways.