罗丹明

中文名称:

罗丹明

中文同义词:

罗丹明110, 激光级;罗丹明110(99%);罗丹明 110 氯化物;罗丹明110;罗明丹110;氯化罗丹明 110;罗丹明;罗丹明560

英文名称:

RHODAMINE 110

英文同义词:

R110;RHODAMINE 110;RHODAMINE 110 CHLORIDE;RHODAMINE 560;RHODAMINE 110 CHLORIDE, FOR FLUOR-ESCENC E;Rhodamine 110, laser grade, pure, 99%;2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid hydrochloride;Exciton Rhodamine 560 Chloride

CAS号:

13558-31-1

分子式:

C20H15ClN2O3

分子量:

366.8

EINECS号:

236-944-7

相关类别:

血液学和组织学;其它试剂;其他生化试剂;染色剂和染料;Amines;Fluorescent Labels Indicators;Heterocycles;Q-R;Stains and Dyes;StainsDyes, A to;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

13558-31-1.mol

熔点 

>300 °C(lit.)

密度 

1.2504 (rough estimate)

折射率 

1.6470 (estimate)

储存条件 

Keep in dark place,Inert atmosphere,Room temperature

溶解度 

ethanol: soluble

形态

Crystalline Powder

颜色

White to light yellow

最大波长(λmax)

499nm (MeOH); 496nm (H2O)

BRN 

4631860

生物领域应用

Detecting risk of Alzheimer’s disease and stroke;evaluating/testing sperm quality; identifying bacteria; as a substrate for measuring aromatase activity, azoreductase activity,phospholipase activity, proteases activity (caspase activity, cathepsin C activity, elastase activity proteinase activity);implantable drug-delivery devices

主要应用

Color filters; liquid crystal displays; dye lasers;electroluminescent displays;inks;light-emitting diode (LED);papermaking process; recording materials; solar cells; silica thin films;sol–gel titania films;waveguides

CAS 数据库

13558-31-1(CAS DataBase Reference)

EPA化学物质信息

Xanthylium, 3,6-diamino-9-(2-carboxyphenyl)-, chloride (13558-31-1)

生物活性

Rhodamine 110 是一种灵敏和选择性的底物 (substrate)，用于测定溶液或活细胞内的蛋白酶。激发波长为 498 nm，发射波长为 521 nm。

体外研究

Rhodamine 110 accumulates in mitochondria in a cationic form, which alters the pH in this cellular compartment. Rhodamine 110 accumulates in human lymphoblastoid cells and Friend leukemia cells. No cytotoxicity to human lymphoblastoid cells is observed below 10 μM, but Rhodamine 110 causes Friend leukemia cells to die at a concentrations above 100 μM.

体内研究

Rhodamine 110 is less toxic than the parent molecule based on the intravenous LD 50 acute toxicity values of 89.5 mg/kg and 140.0 mg/kg for Rhodamine B and Rhodamine 110, respectively. Both molecules induce liver and kidney enlargement after ingestion, and male rats show more significant increases than female rats after Rhodamine 110 exposure. In addition, testis weight increased in male rats dosed with Rhodamine 110. The pharmacokinetics of Rhodamine 110 are assessed following oral administration at two dosages (3 and 10 mg/kg) and intravenous administration at one dosage (3 mg/kg). Pharmacokinetic parameters are calculated using an extravascular input and IV-bolus input, noncompartmental model analysis conducted with WinNonlin Standard Edition. The pharmacokinetic parameters of Rhodamine 110 indicates that the maximum plasma concentrations (C max ) of the two oral dosages are 283.4 and 657.0 ng/mL, which are reached at 140 and 210 min, respectively. This indicates that Rhodamine 110 absorption is not rapid after ingestion, as it took over 2 h to be absorbed from the intestines into the blood. The areas under the concentration–time curves (AUCs) for the two dosages are 138.1±20.3 and 444.0±170.8 h ng/mL. The pharmacokinetic data demonstrate that the AUC is proportional to the administered oral dose of Rhodamine 110 (3 mg/kg and 10 mg/kg). Furthermore, the clearance (Cl) of the two orally administered doses is 7.94 and 8.61 mL/min/kg, respectively.

用途 

激光染料。

危险品标志 

Xn

危险类别码 

22

安全说明 

22-24/25-36/37/39-26

WGK Germany 

3

海关编码 

29329990