别孕烯醇酮

中文名称:

别孕烯醇酮

中文同义词:

异孕烷醇酮;1-[(8R,9S,10S,13S,14S,17S)-3-羟基-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊烷并[A]菲-17-基]乙酮;别孕烷醇酮;别孕烯醇酮 别孕酮中间体;5ALPHA-孕甾-3BETA-醇-20-酮,四氢孕酮(17A,21,21,21-D4,97%+)96%PURE;5ALPHA-孕甾-3BETA-醇--20-酮,四氢孕酮非标;5ALPHA-孕甾-3BETA-醇-20-酮

英文名称:

ALLOPREGNANOLONE

英文同义词:

3-beta-allopregnanolone;3-beta-hydroxy-5-alpha-pregnan-20-on;3-hydroxy-,(3-beta,5-alpha)-pregnan-20-on;3-Hydroxypregnan-20-one;5alpha-Pregnan-20-one, 3beta-hydroxy-;5alpha-Pregnane-3beta-ol-20-one;Allopregnan-3beta-ol-20-one;Allopregnane-3beta-ol-20-one

CAS号:

516-55-2

分子式:

C21H34O2

分子量:

318.49

EINECS号:

208-224-2

相关类别:

中药对照品;Steroids

Mol文件:

516-55-2.mol

熔点 

200℃

比旋光度 

D27 +91.2° (c = 0.4 in ethanol)

沸点 

431.2±18.0 °C(Predicted)

密度 

1.1 g/cm3

酸度系数(pKa)

15.12±0.70(Predicted)

CAS 数据库

516-55-2(CAS DataBase Reference)

用途

异丙孕酮用于制备抗菌和抗白血病类固醇。中间体。

生物活性

Alloepipregnanolone 是一种具有催眠和镇静作用的孕酮，它能干扰乙醇抗焦虑作用的快速耐受。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体内研究

On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol.

RTECS号

TU4383200