表面活性剂SURFACTIN

中文名称:

表面活性剂SURFACTIN

中文同义词:

表面活性剂SURFACTIN;表面活性素

英文名称:

SURFACTIN

英文同义词:

SURFACTIN;surfactin from bacillus subtilis;Surfactin peptide;surfactin C;Biosurfactants Surfactin;Cyclo(L-α-aspartyl-D-leucyl-L-leucyl-3-hydroxy-13-methyltetradecanoyl-L-α-glutamyl-L-leucyl-D-leucyl-L-valyl);Surfactin C1

CAS号:

24730-31-2

分子式:

C53H93N7O13

分子量:

1036.36

EINECS号:

相关类别:

生物化工;中药对照品;化工原料;Antibiotics;Antibiotics A to;Antibiotics N-SAntibiotics;AntifungalAntibiotics;Chemical Structure Class;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Peptides;Spectrum of Activity

Mol文件:

24730-31-2.mol

沸点 

1268.3±65.0 °C(Predicted)

密度 

1.037±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

ethanol: 10 mg/mL, clear, slightly yellow

形态

powder

酸度系数(pKa)

4.00±0.10(Predicted)

颜色

white to faint yellow

稳定性

Stable, but store below 10 C. Incompatible with strong oxidizing agents.

生物活性

Surfactin 是一种环状脂肽生物表面活性剂，可介导单价和二价阳离子 (如钙离子) 穿过脂质双层膜的通量。Surfactin 可以作为抗微生物佐剂，具有抗菌，抗真菌，抗支原体和溶血作用。Surfactin 还对多种包膜病毒具有抗病毒活性。

靶点

HSV-1 HSV-2

HSV-1

HSV-2

体外研究

Surfactin can increase the activity of NSC277174 against avian pathogenic Escherichia coli (APEC) in vitro with antimicrobial assays such as minimum inhibitory concentrations (MIC) and fractional inhibitory concentration (FIC). For APEC O78 strain, the MIC of NSC277174 and Surfactin are 1000 ug/ml and >1mg/ml, respectively.

体内研究

In the model of chick infection (inoculation of E.coli ), Surfactin exerts adjuvant effects with NSC277174 against APEC by lowering the numerical value of mortality and liver bacterial loads, and regulating the expression of inflammatory cytokines et al. Surfactin can act as a novel antimicrobial adjuvant with NSC277174 against AEPC infection in chicken.

WGK Germany 

3

F 

10