4,7-二羟基-2-甲氧基-9,10-二氢菲

中文名称:

4,7-二羟基-2-甲氧基-9,10-二氢菲

中文同义词:

4,7-二羟基-2-甲氧基-9,10-二氢菲

英文名称:

7-Methoxy-9,10-dihydrophenanthrene-2,5-diol

英文同义词:

7-Methoxy-9,10-dihydrophenanthrene-2,5-diol;9,10-Dihydro-2-methoxyphenanthrene-4,7-diol;Lusianthridin;4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene;2,5-Phenanthrenediol, 9,10-dihydro-7-methoxy-

CAS号:

87530-30-1

分子式:

C15H14O3

分子量:

242.27

EINECS号:

相关类别:

对照品;其它酚类;标准品，对照品

Mol文件:

87530-30-1.mol

沸点 

507.3±50.0 °C(Predicted)

密度 

1.296±0.06 g/cm3(Predicted)

酸度系数(pKa)

9.23±0.20(Predicted)

生物活性

Lusianthridin 是来自 Dendrobium venustum 的天然化合物，具有抗迁移作用。Lusianthridin 通过抑制Src-STAT3 信号，促进c-Myc 的降解。

体外研究

Lusianthridin (0-100 μM) inhibits cell viability at concentrations greater than 50 μM in both H460 and H292 cells. Lusianthridin significantly reduces the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentration 5, 10, and 20 μM Lusianthridin, respectively. Cell Viability Assay Cell Line: The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells [1] . 0-100 μM. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.

Cell Line:

The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells [1] . 0-100 μM.

Concentration:

0-100 μM.

Incubation Time:

24 h.

Result:

Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.