印苦楝内酯

中文名称:

印苦楝内酯

中文同义词:

印苦楝内酯

英文名称:

nimbolide

英文同义词:

nimbolide;(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone;NSC 309909;2H,5H-Cyclopenta[d]naphtho[1,8-bc:2,3-b]difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-;methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-bc]difuran-6-yl]acetate

CAS号:

25990-37-8

分子式:

C27H30O7

分子量:

466.52

EINECS号:

相关类别:

化工原料;天然植物分子;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

25990-37-8.mol

熔点 

>223°C (dec.)

沸点 

608.6±55.0 °C(Predicted)

密度 

1.32±0.1 g/cm3(Predicted)

储存条件 

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

形态

powder

生物活性

Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。

靶点

NF-κB CDK4 CDK6

NF-κB

CDK4

用途 

Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cell s at 2.5 - 10 渭M resulted in moderate to very strong growth inhibition.

RTECS号

GY2370000