NULL

中文名称:

NULL

中文同义词:

叔丁氧羰基-三聚乙二醇-溴代;(2-(2-(2-溴乙氧基)乙氧基)乙基)氨基甲酸叔丁酯;2-[2-(2-t-叔丁氧羰基-氨基乙;2-[2-(2-T-叔丁氧羰基-氨基乙;N-BOC-PEG2-BROMIDE,叔丁氧羰基-二聚乙二醇-溴代;2-[2-(2-叔-BOC-氨基乙氧基]乙氧基]乙基溴;溴-二聚乙二醇-氨基叔丁酯;2-[2-(2-T-叔丁氧羰基-氨基乙氧基]乙氧基]乙基溴化物

英文名称:

2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHYL BROMIDE

英文同义词:

2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHYL BROMIDE;2-[2-[2-(tert-ButoxycarbonylaMino)ethoxy]ethoxy]ethyl BroMide;N-[2-[2-(2-BroMoethoxy)ethoxy]ethyl]carbaMic Acid 1,1-DiMethylethyl Ester;tert-Butyl (2-(2-(2-broMoethoxy)ethoxy)ethyl)carbaMate;N-Boc-PEG2-bromide;Br-PEG2-NH-Boc;t-boc-N-amido-PEG3-bromide;BocNH-PEG2-CH2CH2Br

CAS号:

165963-71-3

分子式:

C11H22BrNO4

分子量:

312.2

EINECS号:

相关类别:

其他生化试剂;基准试剂;Nitric Oxide Reagents;Cross Linking Reagents

Mol文件:

Mol File

沸点 

382.8±27.0 °C(Predicted)

密度 

1.257±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

12.22±0.46(Predicted)

稳定性

Light and Moisture Sensitive

CAS 数据库

165963-71-3

生物活性

N-Boc-PEG3-bromide 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG3-bromide 可用于合成一系列 PROTAC 分子。N-Boc-PEG3-bromide 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

靶点

Cleavable PEGs Alkyl/ether

Cleavable

PEGs

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.