N-Boc-PEG4-bromide

中文名称:

N-Boc-PEG4-bromide

中文同义词:

叔丁氧羰基四聚乙二醇溴;N-BOC-PEG4-BROMIDE,叔丁氧羰基-四聚乙二醇-溴代;氨基叔丁氧羰基-四聚乙二醇-溴;溴-四聚乙二醇-氨基叔丁酯

英文名称:

N-Boc-PEG4-bromide

英文同义词:

N-Boc-PEG4-bromide;BocNH-PEG4-CH2CH2Br;N-Boc-PEG5-bromide;Br-PEG4-NHBoc;5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester

CAS号:

1392499-32-9

分子式:

C15H30BrNO6

分子量:

400.31

EINECS号:

相关类别:

Mol文件:

1392499-32-9.mol

沸点 

459.3±40.0 °C(Predicted)

密度 

1.223±0.06 g/cm3(Predicted)

酸度系数(pKa)

12.23±0.46(Predicted)

生物活性

N-Boc-PEG5-bromide 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG5-bromide 可用于合成一系列 PROTAC 分子。N-Boc-PEG5-bromide 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

靶点

Cleavable PEGs Alkyl/ether

Cleavable

PEGs

体外研究

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.