邻苯二甲酸-1-丁酯-2-异丁酯

中文名称:

邻苯二甲酸-1-丁酯-2-异丁酯

中文同义词:

邻苯二甲酸正丁酯异丁酯;别名:1-O-丁基2-O-(2-甲基丙基)苯-1,2-二羧酸酯;邻苯二甲酸-1-丁酯-2-异丁酯

英文名称:

butyl isobutyl phthalate

英文同义词:

butyl isobutyl phthalate;Phthalic acid 1-(2-methylpropyl)2-butyl ester;Phthalic acid 1-butyl 2-isobutyl ester;n-Butyl iso-butyl phthalate;n-Butylisobutyl phthalate (n-Butyl-2-methylpropyl phthalate);1,2-Benzenedicarboxylic acid, 1-butyl 2-(2-methylpropyl) ester

CAS号:

17851-53-5

分子式:

C16H22O4

分子量:

278.34

EINECS号:

241-802-2

相关类别:

合成材料中间体

Mol文件:

17851-53-5.mol

沸点 

315.7±10.0 °C(Predicted)

密度 

1.051±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,Room Temperature

生物活性

Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的，α-glucosidase 的非竞争性抑制剂，其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。

靶点

Target Value α-glucosidase (Cell-free assay) 38 μM

Target

Value

α-glucosidase (Cell-free assay)

38 μM

体外研究

Butyl isobutyl phthalate exhibits significant, concentration-dependent inhibitory activity against α-glucosidase with an IC 50 value of 38 μM.

体内研究

Butyl isobutyl phthalate (intragastric administration; 25, 50 or 100 mg/kg; 3 days) results in a more significant reduction in the blood glucose level, with the concentration of blood glucose being 11.50, 8.60 and 6.50 mM, respectively. Animal Model: Streptozocin induced diabetic mice (Male Kunming mice) Dosage: 25, 50 or 100 mg/kg Administration: Intragastric administration Result: Had the observed antidiabetes activity in mice.

Animal Model:

Streptozocin induced diabetic mice (Male Kunming mice)

Dosage:

25, 50 or 100 mg/kg

Administration:

Intragastric administration

Result:

Had the observed antidiabetes activity in mice.