匹伐他汀内酯

中文名称:

匹伐他汀内酯

中文同义词:

匹伐他汀内酯杂质;4R,6S,E)-6-[2-环丙基-4-(4-氟苯基)-3-喹啉-基-乙烯基]-4-羟基-3,4,5,6-四氢-2H-吡喃-2-酮;(4R,6S,E)-6-[2-[2-环丙基-4-(4-氟苯基)-3-喹啉基]乙烯基]-4-羟基四氢吡喃-2-酮;匹伐他汀内酯;匹伐他汀钙内酯;匹伐他汀杂质A;匹伐他汀钙杂质D;匹伐他汀钙内脂对照品

英文名称:

PITAVASTATIN LACTONE

英文同义词:

PITAVASTATIN LACTONE;Pitavastatin calciuM interMediates to 5, (4R, 6S, E) -6 - [2 - cyclopropyl-4 - (4 - fluorophenyl) -3 - quinoline - yl - vinyl] -4 - hydroxy -3,4,5,6 - tetrahydro-2H-pyran-2 - one;Pitavastatin Lactone DISCONTINUED;(4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl]tetrahydro-4-hydroxypyran-2-one;Pivastatin lactone impurity;Pitavastatin Lactone/Itavastatin Lactone/(4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl] vinyl] tetrahydro-4-hydroxypyran-2-one;(4R,6S)-6-((E)-2-(2-cyclopropyl;Pitavastatin calcium impurity D

CAS号:

141750-63-2

分子式:

C25H22FNO3

分子量:

403.45

EINECS号:

1592732-453-0

相关类别:

医药中间体;中间体;杂质对照品;标准品;对照品-杂质对照品;杂质对照品;All Inhibitors;Inhibitors;Intermediates Fine Chemicals;Pharmaceuticals;标准品

Mol文件:

141750-63-2.mol

熔点 

92-95°C

比旋光度 

D32 +8.84° (c = 0.92 in chloroform)

沸点 

616.9±55.0 °C(Predicted)

密度 

1.372±0.06 g/cm3(Predicted)

酸度系数(pKa)

13.25±0.40(Predicted)

生物活性

Pitavastatin lactone 是 Pitavastatin 在人体中的主要代谢产物。Pitavastatin 是在肝微粒体中很少代谢的 HMG-CoA 还原酶有效的竞争性抑制剂。