硼替佐米杂质E

中文名称:

硼替佐米杂质E

中文同义词:

S,S-异构体;硼替佐米杂质E;BORTEZOMIB杂质 E;(1S,2S)-硼替佐米杂质;硼替佐米杂质 19;硼替佐米杂质PS619;硼替佐米杂质1(S,S-异构体);硼替佐米(1S,2S)

英文名称:

((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid

英文同义词:

((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid;Boronic acid, B-[(1S)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-;(1S,2S)-BortezoMib;(1S,2S)-Bortezomib Impurity;[(1S)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid;Bortezomib Impurity PS619;N-(2-Pyrazinecarbonyl)-L-phenylalanine-D-leucine boronic anhydride;Bortezomib (1S,2S) Isomer Impurity

CAS号:

1132709-14-8

分子式:

C19H25BN4O4

分子量:

384.24

EINECS号:

相关类别:

对照品-杂质对照品;杂质对照品;标准品;Chiral Reagents, Boron Derivatives, Inhibitors, Pharmaceuticals, Intermediates Fine Chemicals

Mol文件:

1132709-14-8.mol

CAS 数据库

1132709-14-8

生物活性

(1S,2S)-Bortezomib 是 Bortezomib 的对映异构体。Bortezomib 是一种细胞渗透性、可逆性和选择性的蛋白酶体抑制剂，通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki 为 0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是一种抗癌药物，也是第一种用于人类的蛋白酶体抑制剂。

靶点

Ki: 0.6 nM (20S proteasome)

用途 

(1S,2S)-Bortezomib is an isomer of Bortezomib (B675700), proteasome inhibitor. (1S,2S)-Bortezomib has been seen to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with A lzheimer鈥檚 or hypertension.