MELEAGRIN

中文名称:

MELEAGRIN

中文同义词:

英文名称:

MELEAGRIN

英文同义词:

[3E,7aR,12aS,(-)]-7a-(1,1-Dimethyl-2-propenyl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazole-4-ylmethylene)-12-methoxy-1H,5H-imidazo[1,2:1,2]pyrido[2,3-b]indole-2(3H),5-dione;Meleagrine;6-O-Methyloxaline, Meleagrine;MELEAGRIN;1H,5H-Imidazo[1,2:1,2]pyrido[2,3-b]indole-2,5(3H)-dione, 7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-, (3E,7aR,12aS)-

CAS号:

71751-77-4

分子式:

C23H23N5O4

分子量:

433.46

EINECS号:

604-604-1

相关类别:

微生物代谢物;医药原料

Mol文件:

71751-77-4.mol

储存条件 

-20°C

形态

Yellow oil.

生物活性

Meleagri 是由青霉属 (Penicillium) 真菌产生的具有抗微生物和抗增殖活性的罗奎福汀 C 衍生生物碱。Meleagrin 是一类 FabI 抑制剂。Meleagri 是一种主要的 c-Met 抑制实体，有助于控制 c-Met 依赖性转移和侵袭性乳腺癌。

体外研究

Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox. Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines.

体内研究

Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model.