N2-去乙酰基-N2-(4-巯基-4-甲基-1-氧代戊基)-6-甲基美登素

中文名称:

N2-去乙酰基-N2-(4-巯基-4-甲基-1-氧代戊基)-6-甲基美登素

中文同义词:

N2-去乙酰基-N2-(4-巯基-4-甲基-1-氧代戊基)-6-甲基美登素;英文名称:MAYTANSINOID DM4

英文名称:

Maytansinoid dM4

英文同义词:

Maytansinoid dM4;N2-deacetyl-n2-(4-Mercapto-4-Methyl-1-oxopentyl)-6-MethylMaytansine;Maytansine, N2-deacetyl-N2-(4-mercapto-4-methyl-1-oxopentyl)-6-methyl-

CAS号:

799840-96-3

分子式:

C39H56ClN3O10S

分子量:

794.4

EINECS号:

相关类别:

医药原料药;医用原料;原料药

Mol文件:

799840-96-3.mol

沸点 

940.2±65.0 °C(Predicted)

密度 

1.28±0.1 g/cm3(Predicted)

酸度系数(pKa)

9.83±0.70(Predicted)

生物活性

Maytansinoid DM4 是一种具有强力细胞毒性的含硫醇美登素衍生物，可用作 ADC 的细胞毒性部分。

靶点

Maytansinoids

Maytansinoids

体外研究

Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus . Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin.