罗红霉素钙盐(链霉菌属载体)

中文名称:

罗红霉素钙盐(链霉菌属载体)

中文同义词:

IONOMYCIN CAICIUM SALT 钙盐;钙离子霉素;罗红霉素钙盐;罗红霉素(游离酸);罗红霉素钙盐(链霉菌属载体);IONOMYCIN CALCIUM SALT 钙离子霉素;离子霉素钙盐;链霉菌属载体

英文名称:

IONOMYCIN CALCIUM SALT

英文同义词:

Calcium ionomycin.;Ionomycin Ca2+ Salt;Ionomycin Ca2+ salt;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2R,5S,5S)-octahydro-5-[(1R)-1-hydroxyethyl]-2,5-dimethyl[2,2-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacidcalciumsalt;Ionomycin, Calcium Salt, Streptomyces conglobatus - CAS 56092-82-1 - Calbiochem;IONOMYCIN CALCIUM (SQ23377 CALCIUM);ATCC 31005;IONOMYCIN (CA)

CAS号:

56092-82-1

分子式:

C41H70CaO9

分子量:

747.07

EINECS号:

617-954-4

相关类别:

合成;化工原料;Ion Channels;antibiotic;Antibiotic Ready Made SolutionsResearch Essentials;Antibiotics;Antibiotics A to;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Chemical Structure Class;Core Bioreagents;Miscellaneous

Mol文件:

56092-82-1.mol

熔点 

205-206 C

闪点 

87 °C

储存条件 

−20°C

溶解度 

Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol

形态

White to off-white solid

颜色

white to off-white

敏感性 

Light Sensitive

BRN 

1416163

生物活性

Ionomycin calcium (SQ23377 calcium) 是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种由 Streptomyces conglobatus 产生的抗生素。Ionomycin calcium (SQ23377 calcium) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin calcium (SQ23377 calcium) 还诱导蛋白激酶C (PKC) 激活。

靶点

Calcium ionophore

体外研究

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus . Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca 2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment. Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.

危险品标志 

Xn

危险类别码 

22

安全说明 

36

WGK Germany 

3

RTECS号

NO0650000

HazardClass 

3

海关编码 

29419090