尾孢菌素

中文名称:

尾孢菌素

中文同义词:

尾孢菌素

英文名称:

CERCOSPORIN

英文同义词:

CGP-049090 (CGP049090;CERCOSPORIN;CERCOSPORIN FROM CERCOSPORA HAYII;6,12-Dihydroxy-8,9-bis(2-hydroxypropyl)-7,10-dimethoxyperylo[1,12-def]-1,3-dioxepin-5,11-dione;6,12-Dihydroxy-7,10-dimethoxy-8,9-bis[(R)-2-hydroxypropyl]perylo[1,12-def]-1,3-dioxepin-5,11-dione;CGP049090, NSC 153111;NSC 153111;CGP-049090

CAS号:

35082-49-6

分子式:

C29H26O10

分子量:

534.51

EINECS号:

相关类别:

微生物代谢物;医药原料;Antibiotics A-F;Antibiotics;Antibiotics A to

Mol文件:

35082-49-6.mol

熔点 

260℃

沸点 

894.7±65.0 °C(Predicted)

密度 

1.59±0.1 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

chloroform: soluble9.80 - 10.20mg/mL, clear, red to red-brown

形态

solid

酸度系数(pKa)

7.76±0.20(Predicted)

生物活性

Cercosporin 由植物病原体 Cercosporakikuchii 和 elsinochromes，elsinoe 家族真菌的色素产生。Cercosporin 是一种有效的光敏剂，具有短的活化波长，主要适用于表面 PDT 光动力研究 (尤其适用于避免穿孔的研究)。Cercosporin 是 PKC 的抑制剂，含有 PKC 活性所必需的醌结构特征, 其 IC50=0.6-1.3 μM。

靶点

IC50: 0.6-1.3 μM (PKC)

体外研究

Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD 50 value for the T98G cells (0.14 J cm 2 ) is much less than the LD 50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm 2 , respectively). Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells. Cell Viability Assay Cell Line: Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7 Concentration: 0 μM, 1 μM, 2 μM, 3 μM Incubation Time: 24 hours Result: Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).

Cell Line:

Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7

Concentration:

0 μM, 1 μM, 2 μM, 3 μM

Incubation Time:

24 hours

Result:

Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).

危险品标志 

Xn

WGK Germany 

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