萘法唑酮盐酸盐

中文名称:

萘法唑酮盐酸盐

中文同义词:

萘法唑酮盐酸盐;盐酸奈法唑酮;盐酸萘法唑酮;盐酸奈法唑酮 标准品;萘法唑酮盐酸盐 USP标准品

英文名称:

Nefazodone hydrochloride

英文同义词:

NEFAZODONE-D5 HCL;3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride;Nefazodone HCl;Nefazodone hydrochloride;NEFAZODONE;BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;Nefazodone Hydrochloride (200 mg)

CAS号:

82752-99-6

分子式:

C25H33Cl2N5O2

分子量:

506.47

EINECS号:

相关类别:

医药原料药;哌嗪;SERZONE;Active Pharmaceutical Ingredients;Serotonin receptor;API;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

82752-99-6.mol

熔点 

186-188°C

储存条件 

Inert atmosphere,Room Temperature

溶解度 

DMSO: ~11 mg/mL at 60 °C

形态

solid

颜色

white

最大波长(λmax)

248nm(MeOH)(lit.)

Merck 

14,6438

CAS 数据库

82752-99-6(CAS DataBase Reference)

生物活性

Nefazodone hydrochloride (BMY-13754) 是一种强效和选择性的 5HT2A (Ki=5.8 nM) 拮抗剂，对 5-HT 和去甲肾上腺素摄取具有中度抑制作用 (IC50 分别为 290 和 300 nM)。Nefazodone hydrochloride 是一种苯哌嗪类抗抑郁药，具有微弱的 α-肾上腺素阻断活性。

靶点

5-HT 2A Receptor 5.8 nM (Ki) α1-adrenergic receptor

5-HT 2A Receptor 5.8 nM (Ki)

α1-adrenergic receptor

体外研究

Nefazodone hydrochloride (BMY-13754) is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. Nefazodone hydrochloride potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake. Nefazodone hydrochloride is also an inhibitor of the hepatic P-450 isoenzyme CYP3A4.

安全说明 

22-24/25

危险品运输编号 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

3

RTECS号

XZ5483009

海关编码 

2933595960