异隐丹参酮

中文名称:

异隐丹参酮

中文同义词:

异隐丹参酮;异丹参酮 III

英文名称:

(8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione

英文同义词:

(+)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione;(8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione;Isotanshinone III;Isocryptotanshinone;Phenanthro[3,2-b]furan-7,11-dione, 1,2,3,4,8,9-hexahydro-4,4,8-trimethyl-, (8S)-

CAS号:

22550-15-8

分子式:

C19H20O3

分子量:

296.36

EINECS号:

相关类别:

中药对照品;标准品 -中药标准品

Mol文件:

22550-15-8.mol

生物活性

Isocryptotanshinone 是一种有效的信号传导与转录激活因子3 (STAT3) 和蛋白酪氨酸磷酸酶1 B (PTP1B) 的抑制剂，其对 PTP1B 的 IC50 值为 56.1 μM。

靶点

STAT3 PTP1B 56.1 μM (IC 50 )

STAT3

PTP1B 56.1 μM (IC 50 )

体外研究

It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner.