伊维菌素 B1A

中文名称:

伊维菌素 B1A

中文同义词:

依维菌素B1A;伊维菌素杂质1

英文名称:

Avermectin A1a, 5-O-demethyl-22,23-dihydro-

英文同义词:

22,23-Dihydro-5-O-demethylavermectin A1a;5-O-Demethyl-22,23-dihydroavermectin A1a;Dihydroavermectin B1a;Ivermectin B1a;IvermectinH2B1a;(2Ae,4E,5S,6S,6R,7S,8E,11R,13R,15S,17ar,20R,20ar,20bs)-20,20B-dihydroxy-5,6,8,19-tetramethyl-6-[(1S)-1-methylpropyl]-17-oxo-3,4,5,6,6,10,11,14,15,17,17A,20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-L-arabino-hexopyranosyl)-3-o-methyl-alpha-L-arabino-hexopyranoside;Avermectin A1a, 5-O-demethyl-22,23-dihydro-;Ivermectin Impurity 3

CAS号:

71827-03-7

分子式:

C48H74O14

分子量:

875.09

EINECS号:

276-046-2

相关类别:

药物杂质及中间体;Organics

Mol文件:

71827-03-7.mol

熔点 

155-157°

沸点 

717.97°C (rough estimate)

密度 

1.0683 (rough estimate)

折射率 

1.6130 (estimate)

酸度系数(pKa)

12.42±0.70(Predicted)

生物活性

Ivermectin B1a 是 Avermectin B1a (HY-15308) 的衍生物，是 Ivermectin (HY-15310) 的主要成分。Ivermectin (MK-933) 是一种广谱抗寄生虫剂。Ivermectin 是应用于抗 SARS-CoV-2/COVID-19 的候选药物。

体外研究

Ivermectin belongs to the macrocyclic lactone class of avermectins and consists of a mixture of two homologous compounds, ivermectin B1a (not less than 80%) and ivermectin B1b (not more than 20%). Ivermectin B1a, the major component of Ivermectin, is inactive at a concentration of 0.3 μg/ml, whereas in the case of the minor component, ivermectin B1b, the same concentration produces 100% mortality of snails.