(3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇

中文名称:

(3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇

中文同义词:

(3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇

英文名称:

Araliadiol

英文同义词:

Araliadiol;(3S,8R,9Z)-1,9-Pentadecadiene-4,6-diyne-3,8-diol;1,9-Pentadecadiene-4,6-diyne-3,8-diol, (3S,8R,9Z)-

CAS号:

1354638-93-9

分子式:

C15H20O2

分子量:

232.32

EINECS号:

相关类别:

其它天然产物

Mol文件:

1354638-93-9.mol

沸点 

381.2±42.0 °C(Predicted)

密度 

1.022±0.06 g/cm3(Predicted)

酸度系数(pKa)

11.69±0.20(Predicted)

生物活性

Araliadiol 是从 Aralia cordata Thunb 的叶子中分离出来的一种聚炔化合物。Araliadiol 抑制 MCF-7 细胞生长，IC50 值为 6.41 µg/mL。

靶点

IC50: 6.41 µg/mL (MCF-7 cells growth)

体外研究

Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition. Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D 3 and cdk4 and an increase in the expression of p21 (WAF-1/Cip1). Cell Cycle Analysis Cell Line: MCF-7 cells Concentration: 20 µM, 40 µM, and 80 µM Incubation Time: 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours Result: The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %). Western Blot Analysis Cell Line: MCF-7 cells Concentration: 20 µM, 40 µM, and 80 µM Incubation Time: 48 hours Result: Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D 3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).

Cell Line:

MCF-7 cells

Concentration:

20 µM, 40 µM, and 80 µM

Incubation Time:

0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours

Result:

The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %).

Cell Line:

MCF-7 cells

Concentration:

20 µM, 40 µM, and 80 µM

Incubation Time:

48 hours

Result:

Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D 3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).