2-甲氧基-4-(2-氨基乙基)苯酚

中文名称:

2-甲氧基-4-(2-氨基乙基)苯酚

中文同义词:

2-甲氧基-4-(2-氨基乙基)苯酚;甲基多巴胺盐酸盐/3-甲氧酪胺盐酸盐;3-甲氧基-4-羟基-β-苯乙胺盐酸盐,3-甲氧基多巴胺盐酸盐;甲基多巴胺盐酸盐;盐酸甲氧酩胺;3-甲氧基色胺盐酸盐 1ML;3-O-甲基多巴胺盐酸盐;3-甲氧基色胺盐酸盐;3-甲氧基对酪胺盐酸盐

英文名称:

3-O-Methyldopamine hydrochloride

英文同义词:

3-O-Methyldopanimehydrochloride;3-O-Methyldopamine hydrochloride, p.a.;RARECHEM AL BW 0216;TIMTEC-BB SBB000426;TIMTEC-BB SBB003882;4-(2-AMINOETHYL)-2-METHOXYPHENOL HYDROCHLORIDE;3-METHOXYTYRAMINE HCL;3-METHOXYTYRAMINE HYDROCHLORIDE

CAS号:

1477-68-5

分子式:

C9H13NO2.ClH

分子量:

203.67

EINECS号:

216-035-1

相关类别:

分析标准品;瘦肉精类;法医和兽医标准品;多巴胺;合成材料中间体;Amines;Bioactive Small Molecules;Building Blocks;C9 to C20+;Cell Biology;Chemical Synthesis;M;Organic Building Blocks;Oxygen Compounds;Phenols;Aromatics;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

1477-68-5.mol

熔点 

213-215 °C(lit.)

闪点 

9℃

储存条件 

-20°C

形态

crystalline

颜色

white to light brown

BRN 

3631283

稳定性

Stable, but may be light sensitive. Combustible. Incompatible with strong oxidizing agents.

生物活性

3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride 是多巴胺的主要细胞外代谢产物，是一种神经调节剂，在某些情况下可能参与运动控制。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

The intensity of the fluorescence developed is in a linear relation to the amount of 3-Methoxytyramine hydrochloride presented in the sample up to at least 1 μg. When a high concentration of dopamine is present in the reaction mixture, there is some reduction in the fluorescence derived from 3-Methoxytyramine hydrochloride.

体内研究

The extracellular DA metabolite 3-Methoxytyramine hydrochloride (3-MT) induces significant behavioral activation in DDD mice. This activity however, is mostly presented as a set of disorganized abnormal movements that includes tremor, head bobbing, straub tail, grooming and abnormal orofacial movements rather than normal forward activity. No effect is observed when 3-Methoxytyramine hydrochloride is infused at doses below 9 µg, at 9 µg and higher doses 3-Methoxytyramine hydrochloride dose-dependently causes transient behavioral activation with a complex set of behaviors. In particular, transient hyperactivity and stereotypy, sniffing, grooming, rearing and mild abnormal involuntary movements (AIMs) at the level of limbs is observed after infusion of 9 µg of 3-Methoxytyramine hydrochloride. Similar behaviors are also observed after 18 µg of 3-Methoxytyramine hydrochloride with the additional appearance of tremor as well as oral and whole body AIMs.

用途 

药物多巴胺的中间体。

用途 

校准仪器和装置；评价方法；工作标准；质量保证/质量控制

生产方法 

由2-甲氧基-4-（2-硝基乙烯）酚还原得到。将2-甲氧基-4-（2-硝基乙烯）酚、乙醇、水、锌粉及盐酸的混合物加热回流3h。冷却，静置过夜。过滤，滤液在10℃左右用碳酸钠中和至pH8-8.5。甩滤，滤液用正丁醇提取。提取液减压蒸馏回收丁醇后冷却，加氯化氢-甲醇回流半小时。冷却，结晶，过滤，滤饼用甲醇洗涤，80℃干燥，得3-O-甲基多巴胺盐酸盐。收率65-70%。

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36-37/39

危险品运输编号 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

3

F 

3-10

HazardClass 

IRRITANT

海关编码 

29222990