相思豆毒素

中文名称:

相思豆毒素

中文同义词:

相思豆毒素;相思豆毒素,L-红豆碱;L-红豆碱;L-ABRINE 相思豆毒素;NΑ-甲基-L-色氨酸;相思豆毒素,L-红豆碱 ,相思豆碱,红豆碱;相思豆毒素标准品;L-(+)-相思子碱

英文名称:

L-ABRINE

英文同义词:

H-METRP-OH;L-ABRINE;ABRINE;ABRINE, L-;N-METHYLTRYPTOPHAN;N-ME-TRP-OH;N-ME-TRP-OH HCL;N-ME-TRYPTOPHAN

CAS号:

526-31-8

分子式:

C12H14N2O2

分子量:

218.25

EINECS号:

208-388-5

相关类别:

标准品;非天然氨基酸衍生物;植物提取物;中药对照品;标准品 -中药标准品;医药原料药;Indoles;Tryptophans;Amino Acid Derivatives;Peptide Synthesis;Tryptophan

Mol文件:

526-31-8.mol

熔点 

>300 °C (dec.)(lit.)

比旋光度 

D21 +44° (0.28 g in 10 ml 0.5N HCl)

沸点 

358.94°C (rough estimate)

密度 

1.272±0.06 g/cm3 (20 ºC 760 Torr)

折射率 

65 ° (C=1, 0.5mol/L NaOH)

储存条件 

Keep in dark place,Inert atmosphere,2-8°C

酸度系数(pKa)

2.32±0.10(Predicted)

旋光性 (optical activity)

[α]20/D +65°, c = 1 in 0.5 M NaOH

Merck 

14,10

BRN 

86638

CAS 数据库

526-31-8(CAS DataBase Reference)

生物活性

L-Abrine (N-Methyl-L-tryptophan)是相思子根部的毒性清蛋白，可抑制核糖体。

体外研究

L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.

体内研究

Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD 50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD 50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.

用途 

一种在体外表现出自由基清除和抗氧化剂特性的吲哚氨基酸。

危险品标志 

Xn

危险类别码 

20/21/22

安全说明 

36

WGK Germany 

3

海关编码 

29339900