2,5-二羟基-4-甲氧基二苯甲酮

中文名称:

2,5-二羟基-4-甲氧基二苯甲酮

中文同义词:

2,5-二羟基-4-甲氧基二苯甲酮

英文名称:

Cearoin

英文同义词:

Cearoin;Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone;(2,5-dihydroxy-4-methoxyphenyl)phenylmethanone;Methanone, (2,5-dihydroxy-4-methoxyphenyl)phenyl-

CAS号:

52811-37-7

分子式:

C14H12O4

分子量:

244.24

EINECS号:

相关类别:

其它酚类

Mol文件:

52811-37-7.mol

熔点 

188 °C(Solv: ethanol (64-17-5))

沸点 

443.8±45.0 °C(Predicted)

密度 

1.296±0.06 g/cm3(Predicted)

酸度系数(pKa)

8.25±0.48(Predicted)

生物活性

Cearoin 可从Dalbergia odorifera中分离，通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。

靶点

ERK ROS Autophagy Apoptosis

ERK

ROS

体外研究

Cearoin (10-80 μM) induces cell death in a dose-dependent manner. Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells. Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process. Cell Viability Assay Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 1, 5, 10, 20, 40, or 80 μM Incubation Time: 6 or 12 hours Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. Western Blot Analysis Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 5, 10, 20, 40, or 80 μM Incubation Time: 12 hours Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner.

Cell Line:

Human neuroblastoma SH-SY5Y cells

Concentration:

0, 1, 5, 10, 20, 40, or 80 μM

Incubation Time:

6 or 12 hours

Result:

Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.

Cell Line:

Human neuroblastoma SH-SY5Y cells

Concentration:

0, 5, 10, 20, 40, or 80 μM

Incubation Time:

12 hours

Result:

Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner.